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Effect of non-random mating on genomic and BLUP selection schemes
Nireaetal.GeneticsSelectionEvolution2012,44:11
/content/44/1/11
G
enetics
Selection
Evolution
RESEARCH
OpenAccess
Effectofnon-randommatingongenomicand
BLUPselectionschemes
KahsayGNirea1*,AnnaKSonesson2,JohnAWoolliams1,3 andTheoHEMeuwissen1
Abstract
Background:Theriskoflong-termunequalcontributionofmatingpairstothegenepoolisthatdeleterious
recessivegenescanbeexpressed.Suchconsequencescouldbealleviatedbyappropriatelydesigningand
optimizingbreedingschemesi.e.byimprovingselectionandmatingprocedures.
Methods:Westudiedtheeffectofmatingdesigns,random,minimumcoancestryandminimumcovarianceof
ancestralcontributionsonrateofinbreedingandgeneticgainforschemeswithdifferentinformationsources,i.e.
sibtestorownperformancerecords,differentgeneticevaluationmethods,i.e.BLUPorgenomicselection,and
differentfamilystructures,i.e.factorialorpair-wise.
Results:Resultsshowedthatsubstantialdifferencesinratesofinbreedingduetomatingdesignwerepresent
underschemeswithapair-wisefamilystructure,forwhichminimumcoancestryturnedouttobemoreeffective
togeneratelowerratesofinbreeding.Specifically,substantialreductionsinratesofinbreedingwereobservedin
schemesusingsibtestrecordsandBLUPevaluation.However,withafactorialfamilystructure,differencesinrates
ofinbreedingduematingdesignswereminor.Moreover,non-randommatinghadonlyasmalleffectinbreeding
schemesthatusedgenomicevaluation,regardlessoftheinformationsource.
Conclusions:ItwasconcludedthatminimumcoancestryremainsanefficientmatingdesignwhenBLUPisused
forgeneticevaluationorwhenthesizeofthepopulationissmall,whereastheeffectofnon-randommatingis
smallerinschemesusinggenomicevaluation.
Background
between mating pairs are minimized to minimize pro-
Selectionandparentmatingpatternsarethetwomajor genyinbreeding[9];withcompensatorymating,parents
components of a breeding program and must be opti- with a small number of selected sibs are preferably
mised with respect to genetic gain (ΔG) and rate of mated to those with a large number of selected sibs
inbree
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