Effect of dsDNA binding to SmD-derived peptides on clinical accuracy in the diagnosis of systemic lupus erythematosus.docVIP

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Effect of dsDNA binding to SmD-derived peptides on clinical accuracy in the diagnosis of systemic lupus erythematosus.doc

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Effect of dsDNA binding to SmD-derived peptides on clinical accuracy in the diagnosis of systemic lupus erythematosus

Available online /content/9/4/R68 Research article Open Access Vol 9 No 4 Effect of dsDNA binding to SmD-derived peptides on clinical accuracy in the diagnosis of systemic lupus erythematosus Michael Mahler1, Aderajew Waka2, F Hiepe3 and Marvin J Fritzler4 1Development and Production, Dr Fooke Laboratorien, Mainstra?e 85, Neuss 41469, Germany 2Charité-University of Medicine Berlin, Internal Medicine Department of Rheumatology and Clinical Immunology German Rheumatism Research Centre of Berlin, Department of Autoimmunology, Charitéplatz 1, 10117 Berlin, Germany 3Medical Clinic for Rheumatology and Clinical Immunology, Charité – Universit?tsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany 4Department of Medicine and Biochemistry Molecular Biology, Faculty of Medicine, University of Calgary, 3330 Hospital Dr. NW, Calgary T2N 4N1, Canada Corresponding author: Michael Mahler, m.mahler.job@web.de Received: 28 Feb 2007 Revisions requested: 11 Apr 2007 Revisions received: 7 Jun 2007 Accepted: 18 Jul 2007 Published: 18 Jul 2007 Arthritis Research Therapy 2007, 9:R68 (doi:10.1186/ar2266) This article is online at: /content/9/4/R68 ? 2007 Mahler et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Systemic lupus erythematosus is characterized by antibodies to a variety of intracellular self-antigens, such as dsDNA and Sm, and these serve as hallmarks in the diagnosis of systemic autoimmune diseases. Several studies have shown that SmD1 and SmD3 synthetic peptides represent highly functional antigens for autoantibody detection and thus for diagnostic applications. The present study analysed the technical and clinical accuracy of an anti-SmD1 (amino acids 83–119) and an anti-SmD3 (amino ac