Effect of Electrospun Non-Woven Mats of Dibutyryl ChitinPoly(Lactic Acid) Blends on Wound Healing in Hairless Mice.docVIP

下载本文档

3
0
约 16页
2017-05-16 发布于上海
举报
版权申诉

Effect of Electrospun Non-Woven Mats of Dibutyryl ChitinPoly(Lactic Acid) Blends on Wound Healing in Hairless Mice.doc

1、本文档共16页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Effect of Electrospun Non-Woven Mats of Dibutyryl ChitinPoly(Lactic Acid) Blends on Wound Healing in Hairless Mice

Molecules 2012, 17, 2992-3007; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Effect of Electrospun Non-Woven Mats of Dibutyryl Chitin/ Poly(Lactic Acid) Blends on Wound Healing in Hairless Mice Seon Il Jang 1, Ji Ye Mok 1, In Hwa Jeon 1, Kwang-Hyun Park 2, Thuy Thi Thu Nguyen 3, Jun Seo Park 3, Hee Min Hwang 4, Mi-Sun Song 4, Duckhee Lee 4 and Kyu Yun Chai 4,* 1 School of Alternative Medicine and Health Science, College of Alternative Medicine, Jeonju University, Jeonju 560-759, Korea; E-Mails: sonjjang@jj.ac.kr (S.I.J.); treehouse@ (J.Y.M.); inflowerj@ (I.H.J.) 2 Department of Biochemistry, Chonbuk National University Medical School, Jeonju 561-756, Korea; E-Mail: khpark@chonbuk.ac.kr 3 Center of Chemical Technology, Division of Chemical Engineering, Hankyong National University, 167 Chungang-ro, Anseong-si, Gyeonggi-do 456-749, Korea; E-Mails: nt.thui82@ (T.T.T.N.); jspark@hknu.ac.kr (J.S.P.) 4 Division of Bio Nano Chemistry, College of Natural Sciences, Wonkwang University, Iksan 570-749, Korea; E-Mails: proteen00@ (H.M.H.); misun4y@ (M.-S.S.); dl202@wonkwang.ac.kr (D.L.) * Author to whom correspondence should be addressed; E-Mail: geuyoon@wonkwang.ac.kr; Tel.: +82-63-850-6230; Fax: +82-63-850-7312. Received: 8 February 2012; in revised form: 4 March 2012 / Accepted: 6 March 2012 / Published: 9 March 2012 Abstract: The aim of this study was to examine the proliferative ability of dibutyryl chitin (DBC) on scratch wounds in HaCaT keratinocytes and to evaluate the effect of nanoporous non-woven mat (DBCNFM) on skin wound healing in hairless mice using the advantages of DBCNFM, such as high porosity and high surface area to volume. The cell spreading activity of DBC was verified through a cell spreading assay in scratched human HaCaT keratinocytes. Scratch wound experiments showed that DBC notably accelerates the spreading rate of HaCaT keratinocytes in a dose dependent manner. The