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Effective x-ray attenuation coefficient measurements from two full field digital mammography systems for data calibration applications.doc

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Effective x-ray attenuation coefficient measurements from two full field digital mammography systems for data calibration applications

BioMedical Engineering OnLine BioMedCentral Research Open Access Effective x-ray attenuation coefficient measurements from two full field digital mammography systems for data calibration applications John J Heine*1 and Jerry A Thomas2 Address: 1Cancer Prevention Control Department, Moffitt Cancer Center, Tampa, Florida, USA and 2Department of Radiology, Via Christi Regional Medical Center, Wichita Kansas, USA Email: John J Heine* - john.heine@; Jerry A Thomas - Jerry_Thomas@ * Corresponding author Published: 28 March 2008 Received: 6 November 2007 Accepted: 28 March 2008 BioMedical Engineering OnLine 2008, 7:13 doi:10.1186/1475-925X-7-13 This article is available from: /content/7/1/13 ? 2008 Heine and Thomas; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Breast density is a significant breast cancer risk factor. Currently, there is no standard method for measuring this important factor. Work presented here represents an essential component of an ongoing project that seeks to determine the appropriate method for calibrating (standardizing) mammography image data to account for the x-ray image acquisition influences. Longer term goals of this project are to make accurate breast density measurements in support of risk studies. Methods: Logarithmic response calibration curves and effective x-ray attenuation coefficients were measured from two full field digital mammography (FFDM) systems with breast tissue equivalent phantom imaging and compared. Normalization methods were studied to assess the possibility of reducing the amount of calibration data collection. The percent glandular calibration map functional form was investigated. Spatial variations in th