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Effects of zinc supplementation on diabetes mellitus a systematic review and meta-analysis
Jayawardenaetal.DiabetologyMetabolicSyndrome2012,4:13
/content/1758-5996/4/1/13
DIABETOLOGY
METABOLIC SYNDROME
REVIEW
OpenAccess
Effectsofzincsupplementationondiabetes
mellitus:asystematicreviewandmeta-analysis
RJayawardena1,2,PRanasinghe1,3*,PGalappatthy3,RLDKMalkanthi4,GRConstantine1andPKatulanda1
Abstract
Thenumberofpeoplewithdiabetesandpre-diabetesareexponentiallyincreasing.Studiesonhumanshaveshown
thebeneficialeffectsofZincsupplementationinpatientswithdiabetes.Thepresentstudyaimstosystematically
evaluatetheliteratureandmeta-analyzetheeffectsofZincsupplementationondiabetes.Asystematicreviewof
publishedstudiesreportingtheeffectsofZincsupplementationsondiabetesmellituswasundertaken.Theliterature
searchwasconductedinthefollowingdatabases;PubMed,WebofScienceandSciVerseScopus.Ameta-analysisof
studiesexaminingtheeffectsofZincsupplementationonclinicalandbiochemicalparametersinpatientswith
diabeteswasperformed.Thetotalnumberofarticlesincludedinthepresentreviewis25,whichincluded3studies
ontype-1diabetesand22studiesontype-2diabetes.Therewere12studiescomparingtheeffectsofZinc
supplementationonfastingbloodglucoseinpatientswithtype-2diabetes.Thepooledmeandifferenceinfasting
bloodglucosebetweenZincsupplementedandplacebogroupswas?18.13mg/dl(95%CI:–33.85,–2.41;p0.05).
2-hpost-prandialbloodsugaralsoshowsasimilardistinctreductionin(?34.87mg/dl[95%CI:–75.44;5.69])theZinc
treatedgroup.ThereductioninHbA1cwas?0.54%(95%CI:–0.86;–0.21)intheZinctreatedgroup.Therewere8
studiescomparingtheeffectsofZincsupplementationonlipidparametersinpatientswithtype-2diabetes.The
pooledmeandifferencefortotalcholesterolbetweenZincsupplementedandplacebogroupswas?32.37mg/dl
(95%CI:–57.39,–7.35;p0.05).Low-densitylipoproteincholesterolalsoshowedasimilardistinctreductioninthe
Zinctreatedgroup,thepooledmeandifferencefromrandomeffectsanalysiswas?11.19mg/dl(95%CI:–21.14,–1.25;
p0.05).StudieshavealsoshownasignificantreductioninsystolicanddiastolicbloodpressuresafterZinc
supplementation.Thisfirstcomprehensives
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