Efficacy and safety of non-invasive ventilation in the treatment of acute cardiogenic pulmonary edema – a systematic review and meta-analysis.docVIP
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Efficacy and safety of non-invasive ventilation in the treatment of acute cardiogenic pulmonary edema – a systematic review and meta-analysis
Available online /content/10/2/R69
Research
Open Access
Vol 10 No 2
Efficacy and safety of non-invasive ventilation in the treatment of
acute cardiogenic pulmonary edema – a systematic review and
meta-analysis
Jo?o C Winck1, Luís F Azevedo2,3, Altamiro Costa-Pereira2,3, Massimo Antonelli4 and
Jeremy C Wyatt5
1Department of Pulmonology, Faculty of Medicine, University of Porto, Portugal
2Department of Biostatistics and Medical Informatics, Faculty of Medicine, University of Porto, Portugal
3Centre for Research in Health Technologies and Information Systems – CINTESIS (Centro de Investiga??o em Tecnologias e Sistemas de
Informa??o em Saúde), Faculty of Medicine, University of Porto, Portugal
4Unita Operativa di Rianimazione e Terapia Intensiva, Instituto di Anestesia e Rianimazione, Policlinico Universitario A Gemelli, Universita Cattolica
del Sacro Cuore, Rome, Italy
5Health Informatics Centre, University of Dundee, Dundee, Scotland, UK
Corresponding author: Luís F Azevedo, lazevedo@med.up.pt
Received: 9 Mar 2006 Accepted: 24 Mar 2006 Published: 28 Apr 2006
Critical Care 2006, 10:R69 (doi:10.1186/cc4905)
This article is online at: /content/10/2/R69
? 2006 Winck et al.; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Introduction Continuous positive airway pressure ventilation
(CPAP) and non-invasive positive pressure ventilation (NPPV)
are accepted treatments in acute cardiogenic pulmonary edema
(ACPE). However, it remains unclear whether NPPV is better
than CPAP in reducing the need for endotracheal intubation
(NETI) rates, mortality and other adverse events. Our aim was to
review the evidence about the efficacy and safety of these two
methods in ACPE management.
therapy (SMT) showed a significant 22% abso
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