Effects of Pithecellobium Jiringa Ethanol Extract against Ethanol-Induced Gastric Mucosal Injuries in Sprague-Dawley Rats.docVIP

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Effects of Pithecellobium Jiringa Ethanol Extract against Ethanol-Induced Gastric Mucosal Injuries in Sprague-Dawley Rats.doc

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Effects of Pithecellobium Jiringa Ethanol Extract against Ethanol-Induced Gastric Mucosal Injuries in Sprague-Dawley Rats

Molecules 2012, 17, 2796-2811; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Effects of Pithecellobium Jiringa Ethanol Extract against Ethanol-Induced Gastric Mucosal Injuries in Sprague-Dawley Rats Ibrahim Abdel Aziz Ibrahim 1,*, Suhailah Wasmn Qader 2, Mahmood Ameen Abdulla 3, Amal R. Nimir 4, Siddig Ibrahim Abdelwahab 5 and Fouad Hussain AL-Bayaty 6 1 Department of Pharmacology, Faculty of Medicine, Universiti Teknology MARA, Shah Alam 40450, Malaysia 2 Department of Biological Science, Faculty of Biosciences and Bioengineering, University of Technology Malaysia, UTM Skudai 81310, Johor, Malaysia; E-Mail: suhaylaqadir@ 3 Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia; E-Mail: mahmood955@ 4 Division of Basic Medical Sciences, Faculty of Medicine, Cyberjaya University College of Medical Sciences (CUCMS), Cyberjaya 63000, Selangor, Malaysia; E-Mail: aralmadi@ 5 Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia; E-Mail: siddigroa@ 6 Department of Restorative Dentistry, Faculty of Dentistry, Universiti Technology MARA, Shah Alam 40450, Malaysia; E-Mail: dribm74@ * Author to whom correspondence should be addressed; E-Mail: jjurishi@; ibrahimabdel@.my; Tel.: +6-03-55-442-973; Fax: +6-03-55-442-831. Received: 31 December 2011; in revised form: 23 February 2012 / Accepted: 23 February 2012 / Published: 6 March 2012 Abstract: Current anti-gastric ulcer agents have side effects, despite the progression and expansion of advances in treatment. This study aimed to investigate the gastroprotective mechanisms of Pithecellobium jiringa ethanol extract against ethanol-induced gastric mucosal ulcers in rats. For this purpose, Sprague Dawley rats were randomly divided into five groups: Group 1 (normal control) rats were orally administered with vehicle (carboxymethyl cellulose),