Effects of high-dose methylprednisolone on neonatal pulmonary function after cardiopulmonary bypass and deep hypothermic circulatory arrest.docVIP

Available online /supplements/5/SB Meeting abstracts Myocardial cell damage and myocardial protection Abstracts of the 3rd International Symposium on the Pathophysiology of Cardiopulmonary Bypass, 16th December 2000, Aachen, Germany Received: 12 February 2001 Published: 6 March 2001 Critical Care 2001, 5(Suppl B):P1–P16 ? 2001 BioMed Central Ltd (Print ISSN 1364-8535; Online ISSN 1466-609X) P1 The use of adenosine as a trigger for pharmacological preconditioning to protect human myocardium during coronary bypass surgery KK Klein, B Korbmacher, U Sunderdiek, E Mohan, E Gams and JD Schipke* Department of Thoracic and Cardiovascular Surgery, and *Research Group Experimental Surgery, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany Introduction: In former studies on ischaemic preconditioning, adenosine was found to trigger this cardioprotective process. After promising experiments in rabbit hearts and the first clini- cal use during emergency percutaneous transluminal coronary angioplasty in patients, we started to investigate the ability of adenosine to protect the myocardium during standard cross- clamping bypass surgery. Because adenosine is metabolized within a few seconds, no systemic effects occur. studied. All patients of both groups were male, had an ejec- tion fraction greater than 50%, and underwent three-vessel bypass during elective cardiac surgery. On first aortic cross- clamping, 5 mg/min adenosine was infused simultaneously with a sufficient blood perfusion via the aortic root over 10 min. The patients in the placebo group received the same dose of physiological saline solution. Blood samples were collected before onset of anaesthesia, before the onset of extracorporeal circulation (ECC), 1 h after the end of surgery, and on the first and second days after surgery in order to assess the following parameters: CK, CK-MB, LDH, GOT, Method: Two gr