Efficacy of antibiotic therapy for SAPHO syndrome is lost after its discontinuation an interventional study.docVIP
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Efficacy of antibiotic therapy for SAPHO syndrome is lost after its discontinuation an interventional study
Available online /content/11/5/R140
Research article
Open Access
Vol 11 No 5
Efficacy of antibiotic therapy for SAPHO syndrome is lost after its
discontinuation: an interventional study
Gunter Assmann1, Olaf Kueck2, Timm Kirchhoff3, Herbert Rosenthal3, Jan Voswinkel1,
Michael Pfreundschuh1, Henning Zeidler4 and Annette D Wagner5
1Department of Rheumatology, University Saarland Medical School Kirrbergerstrasse 1, D66421 Homburg, Germany
2Department of Anaesthesiology, Hospital of Bremerhaven, Wiener Strasse 10, D-27568 Bremerhaven, Germany
3Department of Radiology, University Medical School Hannover, Carl-Neuberg-Strasse 1, D-30625 Hannover, Germany
4Institution of Rheumatologikum Hannover, Carl-Neuberg-Strasse 1, D-30625 Hannover, Germany
5Department of Nephrology, University Medical School Hannover, Carl-Neuberg-Strasse 1, D-30625 Hannover, Germany
Corresponding author: Gunter Assmann, gunter.assmann@uniklinikum-saarland.de
Received: 29 Apr 2009 Revisions requested: 22 Jul 2009 Revisions received: 26 Aug 2009 Accepted: 21 Sep 2009 Published: 21 Sep 2009
Arthritis Research Therapy 2009, 11:R140 (doi:10.1186/ar2812)
This article is online at: /content/11/5/R140
? 2009 Assmann et al.; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Introduction The acronym SAPHO was introduced in 1987 to
unify the various descriptions of a seronegative arthritis
associated with skin manifestations and to show synovitis, acne,
pustulosis, hyperostosis, and osteitis with and without sterile
multifocal osteomyelitis. The etiology of SAPHO syndrome is
unknown, but an association with infection by semipathogenic
bacteria like Propionibacterium acnes has been suggested. We
conducted an interventional study of SAPHO patients
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