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Elevated calcitonin precursor levels are related to mortality in an animal model of sepsis.doc

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Elevated calcitonin precursor levels are related to mortality in an animal model of sepsis

Research paper 11 Elevated calcitonin precursor levels are related to mortality in an animal model of sepsis Paul M Steinwald*, Kevin T Whang?, Kenneth L Becker?, Richard H Snider?, Eric S Nylen? and Jon C White* Background: Increased serum levels of procalcitonin (ProCT) and its component peptides have been reported in humans with sepsis. Using a hamster model of bacterial peritonitis, we investigated whether serum ProCT levels are elevated and correlate with mortality and hypocalcemia. Addresses: *Department of Surgery, Veterans Affairs Medical Center and George Washington University Medical Center, 2150 Pennsylvania Avenue NW, Washington, DC 20037, USA. ?Department of Surgery, Veterans Affairs Medical Center and Georgetown University Medical Results: Incremental increases in doses of bacteria resulted in proportional increases in 72 h mortality rates (0, 20, 70, and 100%) as well as increases in serum total immunoreactive calcitonin (iCT) levels at 12 h (250, 380, 1960, and 4020 pg/ml, respectively, vs control levels of 21pg/ml). Gel filtration studies revealed that ProCT was the predominant (90%) molecular form of serum iCT secreted. In the metabolic experiments, total iCT peaked at 12 h concurrent with the maximal decrease in serum calcium. Center, 3800 Reservoir Road, NW, Washington, DC, USA. ?Section of Endocrinology, Veterans Affairs Medical Center and George Washington University Medical Center, 50 Irving Street NW, Washington, DC 20422, USA. Correspondence: Jon C White, MD, Department of Surgery, Veterans Affairs Medical Center and George Washington University Medical Center, 50 Irving Street NW, Washington, DC 20422, USA Email: jcwhite1@ Conclusions: In this animal model, hyper-procalcitoninemia was an early systemic marker of sepsis which correlated closely with mortality and had an inverse correlation with serum calcium levels. Keywords: inflammation, peritonitis, procalcitonin, prohormone, serum marker Received: 12 August 1997 Revisions requested