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Epstein-Barr Virus (EBV) detection and typing by PCR a contribution to diagnostic screening of EBV-positive Burkitts lymphoma.doc

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Epstein-Barr Virus (EBV) detection and typing by PCR a contribution to diagnostic screening of EBV-positive Burkitts lymphoma

Diagnostic Pathology BioMedCentral Methodology Open Access Epstein-Barr Virus (EBV) detection and typing by PCR: a contribution to diagnostic screening of EBV-positive Burkitts lymphoma Rocío Hassan*1, Lídia Roxana White1, Claudio Gustavo Stefanoff1, Deilson Elgui de Oliveira2, Fabricio E Felisbino1, Claudete Esteves Klumb3, Carlos E Bacchi2, Héctor N Seuánez4 and Ilana R Zalcberg1 Address: 1Bone Marrow Transplantation Center (CEMO), Instituto Nacional de Cancer (INCA), Pra?a Cruz Vermelha 23, 20230-130, 6th floor, Rio de Janeiro, RJ, Brazil, 2Department of Pathology, Botucatu School of Medicine, Universidade Estadual Paulista, S?o Paulo, SP, Brazil, 3Hematology Service, Instituto Nacional de Cancer (INCA), Pra?a Cruz Vermelha 23, 20230-130, Rio de Janeiro, RJ, Brazil and 4Genetics Division, Instituto Nacional de Cancer (INCA), Rua André Cavalcanti 37, 4th floor, 20231-050, Rio de Janeiro, RJ, Brazil Email: Rocío Hassan* - biomol@.br; Lídia Roxana White - biomol@.br; Claudio Gustavo Stefanoff - biomol@.br; Deilson Elgui de Oliveira - elgui@fmb.unesp.br; Fabricio E Felisbino - biomol@.br; Claudete Esteves Klumb - cklumb@.br; Carlos E Bacchi - cebacchi@fmb.unesp.br; Héctor N Seuánez - hseuanez@.br; Ilana R Zalcberg - zalcberg@.br * Corresponding author Published: 07 August 2006 Received: 17 January 2006 Accepted: 07 August 2006 Diagnostic Pathology 2006, 1:17 doi:10.1186/1746-1596-1-17 This article is available from: /content/1/1/17 ? 2006 Hassan et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Epstein-Barr virus (EBV) is associated to the etio-pathogenesis of an increasing number of tumors. Detection of EBV in pathology samples is relevant since its high prevalence in some cancers make