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Establishment of an early liver fibrosis model by the hydrodynamics-based transfer of TGF-β1 gene.doc

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Establishment of an early liver fibrosis model by the hydrodynamics-based transfer of TGF-β1 gene

Comparative Hepatology BioMedCentral Research Open Access Establishment of an early liver fibrosis model by the hydrodynamics-based transfer of TGF-β1 gene Kun-Lin Yang1, Kuo-Chen Hung2, Wen-Teng Chang3 and Eric IC Li*4 Address: 1Institute of Basic Medical Sciences College of Medicine, National Cheng Kung University, Tainan 701, Taiwan, 2Department of General Surgery, E-DA Hospital, I-Shou University, Kaohsiung 824, Taiwan, 3Department of Biological Science and Technology, Chung Hwa University of Medical Technology, Tainan 717, Taiwan and 4Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan Email: Kun-Lin Yang - s5889103@.tw; Kuo-Chen Hung - hcc4723@.tw; Wen- Teng Chang - wtchang@.tw; Eric IC Li* - ericli@.tw * Corresponding author Published: 19 October 2007 Received: 22 May 2007 Accepted: 19 October 2007 Comparative Hepatology 2007, 6:9 doi:10.1186/1476-5926-6-9 This article is available from: /content/6/1/9 ? 2007 Yang et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Liver fibrosis represents a significant and severe health care problem and there are no efficient drugs for therapy so far. Preventing the progression of fibrogenesis and revival endogenous repair activities is an important strategy for both current and future therapies. Many studies of liver fibrosis consist of animal testing with various hepatotoxins. Although this method is often used, the model at which cirrhosis or extensive fibrosis becomes irreversible has not been well defined and is not representative of early-stage fibrogenesis. We here report the establishment of a transient and reversible liver fibrosis animal model which may better represent an ea