Ethyl 3-{2-[(3-Methyl-1H-indol-2-yl)carbonyl]-hydrazinylidene}-butanoate.docVIP

Molbank 2012, M749; doi:10.3390/M749 OPEN ACCESS molbank ISSN 1422-8599 /journal/molbank Short Note Ethyl 3-{2-[(3-Methyl-1H-indol-2-yl)carbonyl]hydrazinylidene}- butanoate Thoraya A. Farghaly and Sobhi M. Gomha * Department of Chemistry, Faculty of Science, University of Cairo, Giza 12613, Egypt * Author to whom correspondence should be addressed; E-Mail: s.m.gomha@. Received: 6 January 2012 / Accepted: 4 February 2012 / Published: 7 February 2012 Abstract: The title compound, ethyl 3-{2-[(3-methyl-1H-indol-2-yl)carbonyl]hydrazinylidene} butanoate (3), was prepared via reaction of 3-methyl-1H-indole-2-carbohydrazide (1) and ethyl 3-oxobutanoate (2) under reflux. The structure of the synthesized compound was assigned on the basis of elemental analysis, IR, 1H-NMR, mass spectral and X-ray data. Keywords: 3-methyl-1H-indole-2-carbohydrazide; X-ray Indoles are among the most important nitrogen-containing heterocyclic molecules, found extensively in biological systems which play a vital role in biochemical processes. The indole ring system is found in many natural products, pharmaceutical agents and polymer materials [1–7]. The interesting chemical properties of indole have inspired chemists to design and synthesize a variety of indole derivatives [8]. In view of this finding, in the present paper we describe the synthesis of a new indole derivative with expected biological activity. Results and Discussion 3-Methyl-1H-indole-2-carbohydrazide (1) [9] was allowed to react with ethyl 3-oxobutanoate (2) in ethanolic solution under reflux. The expected product of this reaction was assumed to be one of the seven structures 3–9 shown in Scheme 1. IR, 1H-NMR, mass spectral data and single-crystal X-ray diffraction studies (Figure 1 and Table 1) of the isolated product were in full agreement with the structure 3, but not with the other structures 4–9.  Molbank 2012 M749 (Page 2) Scheme 1. S