Ethyl 7-Methyl-5-(4-methylphenyl)-3-oxo-2-{[3-(3,4-dichlorophenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate.docVIP

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Ethyl 7-Methyl-5-(4-methylphenyl)-3-oxo-2-{[3-(3,4-dichlorophenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate.doc

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Ethyl 7-Methyl-5-(4-methylphenyl)-3-oxo-2-{[3-(3,4-dichlorophenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate

Molbank 2012, M776; doi:10.3390/M776 OPEN ACCESS molbank ISSN 1422-8599 /journal/molbank Short Note Ethyl 7-Methyl-5-(4-methylphenyl)-3-oxo-2-{[3-(3,4- dichlorophenyl)-1-phenyl-1H-pyrazol-4-yl]methylidene}-2,3- dihydro-5H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate Shivapura Viveka 1, Dinesha 1, Sandeep Sadananda Laxmeshwar 2 and Gundibasappa Karikannar Nagaraja 1,* 1 Department of Studies in Chemistry, Mangalore University, Mangalagangotri-574 199, Karnataka, India 2 Post-Graduate Department of Studies and Research in Polymer Science, Sir M. V. PG Centre, University of Mysore, Mandya-571402, Karnataka, India * Author to whom correspondence should be addressed; E-Mail: nagarajagk@. Received: 10 August 2012 / Accepted: 31 August 2012 / Published: 7 September 2012 Abstract: A simple route for synthesis of compound 3 via three component reaction involving ethyl 6-methyl-4-(4-methylphenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5- carboxylate (1), 3-(3,4-dichlorophenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde (2) and monochloroacetic acid is described. The newly synthesized compound is well characterized by elemental analysis, IR, 1H-NMR and mass spectral studies. Keywords: thiazolo[3,2-a]pyrimidine; 1,3-diphenyl-1H-pyrazole-4-carbaldehyde; multi- component reaction Introduction Pyrimidine derivatives have been reported to possess a broad spectrum of pharmacological properties including antiviral, antiumor, antibacterial and antihypertensive effects [1,2]. Thiazoles and their derivatives are also found to be associated with various biological activities such as antifungal, antibacterial and anti-inflammatory [3–5]. Thiazolo[3,2-a]pyrimidine systems have been known for their unique pharmaceutical and medicinal applications [6,7]. On the other hand the synthesis and the chemistry of the pyrazole nucleus has received much attention during recent decades due to its outstanding biol