Evaluation of Antioxidant and Immunity Function of Tetramethylpyrazine Phosphate Tablets in Vivo.docVIP

Molecules 2012, 17, 5412-5421; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Evaluation of Antioxidant and Immunity Function of Tetramethylpyrazine Phosphate Tablets in Vivo Ling Guo 1, Aihong Wang 1, Yongle Sun 1 and Chongen Xu 2,* 1 Department of Cardiology, Provincial Hospital Affiliated to Shandong University, 324# Jingwu-Weiqi Road, Jinan 250021, China; E-Mails: lguodrjn@163.com (L.G.); ahwangdf@163.com (A.W.); ylsunfjh@163.com (Y.S.) 2 Department of Cardiac Surgery, Provincial Hospital Affiliated to Shandong University, 324# Jingwu-Weiqi Road, Jinan 250021, China * Author to whom correspondence should be addressed; E-Mail: glxrp1@163.com; Tel.: +86-158-652-689-26; Fax: +86-531-851-878-34. Received: 16 April 2012; in revised form: 28 April 2012 / Accepted: 28 April 2012 / Published: 8 May 2012 Abstract: The aim of the study was to determine the effect of tetramethylpyrazine phosphate tablets (TPT), a Chinese medicine used for cardiovascular disease, on immunity activity and oxidative injury in rats. Heart failure (HF) was induced by isoproterenol (ISO). After the animal model was established, the rats were administered the TPT by gavage (once a day). The results indicated that TPT improved left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), ±dP/dt, heart weight/body weight. TPT could decrease the levels of tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6). Furthermore, it also could raise the activities of catalase, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), but reduce malonyldialdehyde (MDA) level. The results indicated that TPT improved cardiac function and myocardial fibrosis from myocardial injury, and this cardioprotection might be attributed to a reduction of oxidative stress and regulation of inflammation mediators. Keywords: tetramethylpyrazine phosphate tablets; LVEDP; LV