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Ethnicity and gender related differences in extended intraesophageal pH monitoring parameters in infants a retrospective study.doc

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Ethnicity and gender related differences in extended intraesophageal pH monitoring parameters in infants a retrospective study

BMC Pediatrics BioMedCentral Research article Open Access Ethnicity and gender related differences in extended intraesophageal pH monitoring parameters in infants: a retrospective study Dena Nazer*1, Ronald Thomas2 and Vasundhara Tolia1 Address: 1Childrens Hospital of Michigan, Carman and Ann Adams Department of Pediatrics, 3901 Beaubien Street, Detroit, MI 48201, USA and 2Childrens Research Center of Michigan, 3901 Beaubien Street, Detroit, MI 48201, USA Email: Dena Nazer* - nazer@; Ronald Thomas - rthomas@; Vasundhara Tolia - vtolia@ * Corresponding author Published: 18 July 2005 Received: 28 February 2005 Accepted: 18 July 2005 BMC Pediatrics 2005, 5:24 doi:10.1186/1471-2431-5-24 This article is available from: /1471-2431/5/24 ? 2005 Nazer et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Gastroesophageal reflux disease (GERD) is believed to be more common in adult males as compared to females. It also has been shown in adults to be more common in Caucasians. We wanted to determine ethnicity and gender related differences for extended pH monitoring parameters in infancy. Methods: Extended pH monitoring data (EPM) from infants 1 year of age were reviewed. Results were classified in two groups, as control and Gastroesophageal reflux disease (GERD) group based on the reflux index (RI). The GERD group had RI of equal to or more than 5% of total monitoring period. The parameters of RI, total number of episodes of pH 4, and the number of episodes with pH 4 lasting more than 5 minutes were compared by genders and by ethnic groups, Caucasians and African American (AA). Results: There were 569 infants, 388 controls, 181 with GERD (320 males, 249 females; 165 Caucasians, 375 AA).