Evaluation of in Vivo Antioxidant and Immunity Enhancing Activities of Sodium Aescinate Injection Liquid.docVIP

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Evaluation of in Vivo Antioxidant and Immunity Enhancing Activities of Sodium Aescinate Injection Liquid.doc

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Evaluation of in Vivo Antioxidant and Immunity Enhancing Activities of Sodium Aescinate Injection Liquid

Molecules 2012, 17, 10267-10275; doi:10.3390/molecules170910267 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Evaluation of in Vivo Antioxidant and Immunity Enhancing Activities of Sodium Aescinate Injection Liquid Yong-Kun Wang 1,?, Jiang Han 2,?, Wu-Jun Xiong 1,?, Qiong-Ying Yuan 1, Yan-Ping Gu 1, Jun Li 1, Zhe Zhu 1, Hui Zhang 1,* and Cong-Jun Wang 1,* 1 Department of Hepatobiliary Pancreatic Diseases, School of Medicine, Shanghai East Hospital, Tongji University, Shanghai 200120, China 2 Department of General Surgery, Pudong New Area Zhoupu Hospital, Shanghai 201318, China ? These authors contributed equally to this work. * Authors to whom correspondence should be addressed; E-Mails: hzhang351@126.com (H.Z.); cjwangsgrei@126.com (C.-J.W.); Tel./Fax: +86-021-5670-3724. Received: 29 June 2012; in revised form: 13 August 2012 / Accepted: 14 August 2012 / Published: 27 August 2012 Abstract: Oxidative stress is involved in the development and progression of disease. Because sodium aescinate has been reported to have immunity enhancing and antioxidative effects, we investigated its activity by employing a hepatocellular carcinoma (HCC) mouse model. Sixty BALB/c mice were randomly divided into four groups, including a 1.4 mg/kg treated group (n = 15), a 2.8 mg/kg treated group (n = 15), an untreated hepatocellular carcinoma control group (n = 15) and a normal control group (n = 15). After H22 cells were cultured for one week, we collected 2 × 106 cells and injected them subcutaneously as 0.2 mL cell suspensions in sterile saline into the right shoulder region of every mouse. The animals were monitored for changes in activity, physical condition and body weight during the experiment. The next day after injection of H22 cells, animals in these test groups received one intraperitoneal injection of drug or physiological saline for 13 days. Results showed that in the sodium aescinate injection liq