Evaluation of the Inheritance of the Complex Vertebral Malformation Syndrome by Breeding Studies.docVIP

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Evaluation of the Inheritance of the Complex Vertebral Malformation Syndrome by Breeding Studies.doc

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Evaluation of the Inheritance of the Complex Vertebral Malformation Syndrome by Breeding Studies

Acta vet. scand. 2004, 45, 133-137. Evaluation of the Inheritance of the Complex Vertebral Malformation Syndrome by Breeding Studies By J. S. Agerholm1, O. Andersen3, M. B. Almskou3, C. Bendixen4, J. Arnbjerg2, G. P. Aamand3, U. S. Nielsen3, F. Panitz4, and A.H. Petersen4 1Laboratory of Pathology, Department of Veterinary Pathobiology and 2Department of Clinical Studies, Radiol- ogy, The Royal Veterinary and Agricultural University, Frederiksberg, 3Danish Cattle, Skejby, and 4Institute of Agricultural Sciences, Department of Animal Breeding and Genetics, Tjele, Denmark. Agerholm JS, Andersen O, Almskou MB, Bendixen C, Arnbjerg J, Aamand GP, Nielsen US, Panitz F, Petersen AH: Evaluation of the inheritance of the complex vertebral malformation syndrome by breeding studies. Acta vet. scand. 2004, 45, 133-137. – To investigate the congenital complex vertebral malformation syndrome (CVM) in Holstein calves, two breeding studies were performed including 262 and 363 cows, respectively. Cows were selected from the Danish Cattle Database based on pedi- gree and insemination records. Selected cows were progeny of sires with an established heterozygous CVM genotype and pregnant after insemination with semen from another sire with heterozygous CVM genotype. Following calving the breeders should state, if the calf was normal and was requested to submit dead calves for necropsy. In both stud- ies, signi?cantly fewer CVM affected calves than expected were obtained; a ?nding probably re?ecting extensive intrauterine mortality in CVM affected foetuses. The ?nd- ings illustrate increased intrauterine mortality as a major potential bias in observational studies of inherited disorders. Complex vertebral malformation; CVM; abortion; congenital; Holstein; cattle. Introduction Complex vertebral malformation (CVM) is a lethal syndrome of Holstein cattle, which in premature and mature calves is characterised by congenital growth retardation, malformed ver- t