Evaluation of Antioxidant and Immunity-Enhancing Activities of Sargassum pallidum Aqueous Extract in Gastric Cancer Rats.docVIP

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Evaluation of Antioxidant and Immunity-Enhancing Activities of Sargassum pallidum Aqueous Extract in Gastric Cancer Rats.doc

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Evaluation of Antioxidant and Immunity-Enhancing Activities of Sargassum pallidum Aqueous Extract in Gastric Cancer Rats

Molecules 2012, 17, 8419-8429; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Evaluation of Antioxidant and Immunity-Enhancing Activities of Sargassum pallidum Aqueous Extract in Gastric Cancer Rats Rui-Li Zhang 1, Wen-Da Luo 2,*, Tie-Nan Bi 1 and Shen-Kang Zhou 1 1 Department of Gastrointestinal Surgery, Taizhou Hospital of Zhejiang Province, Wenzhou Medical College, Linhai 317000, China; E-Mail: rlzhanglhd@163.com (R.-L.Z.); tnbilhd@163.com (T.-N.B.); skzhoulhd@163.com (S.-K.Z.) 2 Division of Hematology and Medical Oncology, Taizhou Hospital of Zhejiang Province, Wenzhou Medical College, Linhai 317000, China * Author to whom correspondence should be addressed; E-Mail: wdluolhd@163.com; Tel./Fax: +86-0576-8512-0120. Received: 23 May 2012; in revised form: 28 June 2012 / Accepted: 29 June 2012 / Published: 11 July 2012 Abstract: The effect of Sargassum pallidum (brown seaweed) aqueous extract on the immunity function and antioxidant activities in was studied gastric cancer rats. Treatment with Sargassum pallidum aqueous extract at oral doses 400, 600 or 800 mg/kg body weight was found to provide a dose-dependent protection against N-methyl-N′-nitro-N- nitrosoguanidine (MNNG)-induced immunity damage and oxidative injury by enhancing serum interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-10 (IL-10) levels, decreasing interleukin-6 (IL-6), interleukin-1β (IL-1β), tumor necrosis factor-alpha (TNF-α) levels, preserving normal antioxidant enzymes activities, and by inhibiting lipid peroxidation in gastric mucosa. It can be concluded that Sargassum pallidum aqueous extract may enhance the immunity and antioxidant activities in gastric cancer rats. Keywords: Sargassum pallidum aqueous extract; IL-2; IL-4; TNF-α; antioxidant 1. Introduction Gastric cancer is the second commonest cause of death from malignant disease worldwide [1]. Antioxidant compounds,