Evaluation of the soft tissue biocompatibility of MgCa0.8 and surgical steel 316L in vivo a comparative study in rabbits.docVIP

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Evaluation of the soft tissue biocompatibility of MgCa0.8 and surgical steel 316L in vivo a comparative study in rabbits.doc

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Evaluation of the soft tissue biocompatibility of MgCa0.8 and surgical steel 316L in vivo a comparative study in rabbits

Erdmannetal.BioMedicalEngineeringOnLine2010,9:63 /content/9/1/63 RESEARCH OpenAccess Evaluationofthesofttissuebiocompatibilityof MgCa0.8andsurgicalsteel316Linvivo:a comparativestudyinrabbits NinaErdmann1*,AlexandrBondarenko1,MarionHewicker-Trautwein2,NinaAngrisani1,JaninReifenrath1, ArneLucas3,AndreaMeyer-Lindenberg1 *Correspondence:nina. Abstract erdmann@tiho-hannover.de 1SmallAnimalClinic,Universityof VeterinaryMedicineHannover, Background:Recentstudieshaveshownthepotentialsuitabilityofmagnesium alloysasbiodegradableimplants.Theaimofthepresentstudywastocomparethe Bünteweg9,30559Hannover, Germany softtissuebiocompatibilityofMgCa0.8andcommonlyusedsurgicalsteelinvivo. Methods:Abiodegradablemagnesiumcalciumalloy(MgCa0.8)andsurgicalsteel (S316L),asacontrol,wereinvestigated.Screwsofidenticalgeometricalconformation wereimplantedintothetibiaeof40rabbitsforapostoperativefollowupoftwo, four,sixandeightweeks.Thetibialiscranialismusclewasindirectvicinityofthe screwheadandthusembeddedinparaffinandhistologicallyand immunohistochemicallyassessed.Haematoxylinandeosinstainingwasperformedto identifymacrophages,giantcellsandheterophilgranulocytesaswellastheextentof tissuefibrosisandnecrosis.Mouseanti-CD79aandratanti-CD3monoclonalprimary antibodieswereusedforB-andT-lymphocytedetection.Evaluationofallsections wasperformedbyapplyingasemi-quantitativescore. Results:Clinically,bothimplantmaterialsweretoleratedwell.Histologyrevealedthat alayeroffibroustissuehadformedbetweenimplantandoverlyingmusclein MgCa0.8andS316L,whichwasdemarcatedbyalayerofsynoviocyte-likecellsatits interfacetotheimplant.InMgCa0.8implantscavitiesweredetectedwithinthe fibroustissue,whichweresurroundedbythesamekindofcelltype.Thethicknessof thefibrouslayerandtheamountoftissuenecrosisandcellularinfiltrationsgradually decreasedinS316L.Incontrast,adecreasecouldonlybenotedinthefirstweeksof implantationinMgCa0.8,whereasparameterswereincreasingagainattheendof theobservationperiod.B-lymphocyteswerefoundmoreofteninMgCa0.8indic