Evolution of protein complexes by duplication of homomeric interactions.docVIP

Open Access Re rch 2007Pereira-LealetVoal.lumesea8, Issue 4, Article R51 Evolution of protein complexes by duplication of homomeric interactions Jose B Pereira-Leal*?, Emmanuel D Levy?, Christel Kamp? and Sarah A Teichmann? Addresses: *Instituto Gulbenkian de Ciência, Apartado 14, P-2781-901 Oeiras, Portugal. ?MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK. ?Paul-Ehrlich-Institut, Federal Agency for Sera and Vaccines, Paul-Ehrlich-Stra?e, 63225 Langen, Germany. Correspondence: Jose B Pereira-Leal. Email: jleal@igc.gulbenkian.pt Published: 5 April 2007 Received: 3 October 2006 Revised: 15 January 2007 Accepted: 5 April 2007 Genome Biology 2007, 8:R51 (doi:10.1186/gb-2007-8-4-r51) The electronic version of this article is the complete one and can be found online at /2007/8/4/R51 ? 2007 Pereira-Leal et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. oProteinpfpcoAmsptiucomplexlnedtxyeersoafocytfiepoaevolutionanstrsaproteinilnogthoeusnepcomplexes,trwooteriknsso.f/specomplexesveral organofisknownms revethree-dimensionalaled that duplicatiostructuren of hominomtheeriProteinc in racDatationsBankoftenandresuclustersts in thofe fopair-wisermation Abstract Background: Cellular functions are accomplished by the concerted actions of functional modules. The mechanisms driving the emergence and evolution of these modules are still unclear. Here we investigate the evolutionary origins of protein complexes, modules in physical protein-protein interaction networks. Results: We studied protein complexes in Saccharomyces cerevisiae, complexes of known three- dimensional structure in the Protein Data Bank and clusters of pairwise protein interactions in the networks of several organisms. We found