Evolutionary conservation of domain-domain interactions.docVIP

Open Access Re rch 2006ItzhakietVoal.lumesea7, Issue 12, Article R125 Evolutionary conservation of domain-domain interactions Zohar Itzhaki, Eyal Akiva, Yael Altuvia and Hanah Margalit Address: Department of Molecular Genetics and Biotechnology, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel. Correspondence: Hanah Margalit. Email: hanah@md.huji.ac.il Published: 21 December 2006 Received: 16 August 2006 Revised: 6 November 2006 Accepted: 21 December 2006 Genome Biology 2006, 7:R125 (doi:10.1186/gb-2006-7-12-r125) The electronic version of this article is the complete one and can be found online at /2006/7/12/R125 ? 2006 Itzhaki et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ConservationthpatMthaeprep insgaofcadinteractingtaolmogauine-odfodmdomainsoainmaiinteractionsn pairs that iontos usethed focellularr mediatprotein-proteining various inteinteractionractions in tnetworkshe cell/pofdifferent organisms demonstrates Abstract Background: Recently, there has been much interest in relating domain-domain interactions (DDIs) to protein-protein interactions (PPIs) and vice versa, in an attempt to understand the molecular basis of PPIs. Results: Here we map structurally derived DDIs onto the cellular PPI networks of different organisms and demonstrate that there is a catalog of domain pairs that is used to mediate various interactions in the cell. We show that these DDIs occur frequently in protein complexes and that homotypic interactions (of a domain with itself) are abundant. A comparison of the repertoires of DDIs in the networks of Escherichia coli, Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, and Homo sapiens sho