Evolutionary conservation of regulated longevity assurance mechanisms.docVIP

Open Access Re rch 2007McElweeetVoal.lumesea8, Issue 7, Article R132 Evolutionary conservation of regulated longevity assurance mechanisms Joshua J McElwee¤*?, Eugene Schuster¤?, Eric Blanc¤?, Matthew D Piper*, James H Thomas?, Dhaval S Patel*, Colin Selman§, Dominic J Withers§, Janet M Thornton?, Linda Partridge* and David Gems* Addresses: *Department of Biology, University College London, London WC1E 6BT, UK. ?Department of Genome Sciences, University of Washington, Seattle, Washington 98195-5065, USA. ?European Bioinformatics Institute, Hinxton CB10 1SD, UK. §Department of Medicine, University College London, London WC1E 6BT, UK. ¤ These authors contributed equally to this work. Correspondence: David Gems. Email: david.gems@ucl.ac.uk Published: 5 July 2007 Received: 5 December 2006 Revised: 16 May 2007 Accepted: 5 July 2007 Genome Biology 2007, 8:R132 (doi:10.1186/gb-2007-8-7-r132) The electronic version of this article is the complete one and can be found online at /2007/8/7/R132 ? 2007 McElwee et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. EvolutionmputaSnhtonrteamofbaslongevityttoradcets:,Afrmuregulationitulti-levelfl es andcross-speciesmice with redcomparativeuced insulinanalysis/IGF-1 siofgngene-expressionaling revealed cachangesndidate caccompanyingonserved mechincreasedanisms.longevity/p in Abstract Background: To what extent are the determinants of aging in animal species universal? Insulin/ insulin-like growth factor (IGF)-1 signaling (IIS) is an evolutionarily conserved (public) regulator of longevity; yet it remains unclear whether the genes and biochemical processes through which IIS acts on aging are public or private (that is, lineage specific). To address this, we have applied a novel, m