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Event-related potential studies of post-traumatic stress disorder a critical review and synthesis.doc

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Event-related potential studies of post-traumatic stress disorder a critical review and synthesis

Biology of Mood Anxiety Disorders Event-relatedpotentialstudiesofpost-traumatic stressdisorder:acriticalreviewandsynthesis Javanbakhtetal. Javanbakhtetal.BiologyofMoodAnxietyDisorders2011,1:5 /content/1/1/5(12October2011) Javanbakhtetal.BiologyofMoodAnxietyDisorders2011,1:5 /content/1/1/5 Biology of Mood Anxiety Disorders REVIEW OpenAccess Event-relatedpotentialstudiesofpost-traumatic stressdisorder:acriticalreviewandsynthesis ArashJavanbakht1,2*,IsraelLiberzon1,AlirezaAmirsadri2,KlevestGjini2andNashNBoutros2 Abstract Despitethesparsenessofthecurrentlyavailabledata,thereisaccumulatingevidenceofinformationprocessing impairmentinpost-traumaticstressdisorder(PTSD).Studiesofevent-relatedpotentials(ERPs)arethemaintoolin realtimeexaminationofinformationprocessing.Inthispaper,wesoughttocriticallyreviewtheERPevidenceof informationprocessingabnormalitiesinpatientswithPTSD.Wealsoexaminedtheevidencesupportingthe existenceofarelationshipbetweenERPabnormalitiesandsymptomprofilesorseverityinPTSDpatients.An extensiveMedlinesearchwasperformed.KeywordsincludedPTSDorpost-traumaticstressdisorder, electrophysiologyorEEG,electrophysiology,P50,P100,N100,P2,P200,P3,P300,sensorygating,CNV(contingent negativevariation)andMMN(mismatchnegativity).WelimitedthereviewtoERPadulthumanstudieswith controlgroupswhichwerereportedintheEnglishlanguage.Afterapplyingourinclusion-exclusionreviewcriteria, 36studieswereincluded.Subjectsexposedtowiderangesofmilitaryandciviliantraumaswerestudiedinthese reports.Presentedstimuliwerebothauditoryandvisual.ThemostwidelystudiedcomponentsincludedP300,P50 gating,N100andP200.MostofthestudiesreportedincreasedP300responsetotrauma-relatedstimuliinPTSD patients.Asmallergroupofstudiesreporteddampeningofresponsesornochangeinresponsestotrauma-related and/orunrelatedstimuli.P50studieswerestronglysuggestiveofimpairedgatinginpatientswithPTSD.In conclusion,themajorityofreportssupportevidenceofinformationprocessingabnormalitiesinpatientswithPTSD diagnosis.Thepredominanceof