Exploiting Surface Plasmon Resonance (SPR) Technology for the Identification of Fibroblast Growth Factor-2 (FGF2) Antagonists Endowed with Antiangiogenic Activity.docVIP

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Exploiting Surface Plasmon Resonance (SPR) Technology for the Identification of Fibroblast Growth Factor-2 (FGF2) Antagonists Endowed with Antiangiogenic Activity.doc

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Exploiting Surface Plasmon Resonance (SPR) Technology for the Identification of Fibroblast Growth Factor-2 (FGF2) Antagonists Endowed with Antiangiogenic Activity

Sensors 2009, 9, 6471-6503; doi:10.3390/OPEN ACCESS sensors ISSN 1424-8220 /journal/sensors Review Exploiting Surface Plasmon Resonance (SPR) Technology for the Identification of Fibroblast Growth Factor-2 (FGF2) Antagonists Endowed with Antiangiogenic Activity Marco Rusnati 1, Antonella Bugatti 1, Stefania Mitola 1, Daria Leali 1, Paolo Bergese 2, Laura E. Depero 2 and Marco Presta 1,* 1 Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, Brescia, 25123, Italy; E-Mails: rusnati@med.unibs.it (M.R.); bugatti@med.unibs.it (A.B.); mitola@med.unibs.it (S.M.); leali@med.unibs.it (D.L.); 2 Chemistry for Technologies Laboratory and Department of Mechanical and Industrial Engineering, School of Engineering, University of Brescia, Brescia, 25123, Italy; E-Mails: paolo.bergese@ing.unibs.it (P.B.); depero@ing.unibs.it (L.E.D.) * Author to whom correspondence should be addressed: E-Mail: presta@med.unibs.it; Tel.: 39-030-371 7310; Fax: 39-030-370 1157 Received: 24 July 2009; in revised form: 17 August 2009 / Accepted: 19 August 2009 / Published: 20 August 2009 Abstract: Angiogenesis, the process of new blood vessel formation, is implicated in various physiological/pathological conditions, including embryonic development, inflammation and tumor growth. Fibroblast growth factor-2 (FGF2) is a heparin-binding angiogenic growth factor involved in various physiopathological processes, including tumor neovascularization. Accordingly, FGF2 is considered a target for antiangiogenic therapies. Thus, numerous natural/synthetic compounds have been tested for their capacity to bind and sequester FGF2 in the extracellular environment preventing its interaction with cellular receptors. We have exploited surface plasmon resonance (SPR) technique in search for antiangiogenic FGF2 binders/antagonists. In this review we will summariz