Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc.docVIP
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Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc
Available online /content/10/4/R99
Research article
Open Access
Vol 10 No 4
Expression and regulation of neurotrophins in the nondegenerate
and degenerate human intervertebral disc
Devina Purmessur, Anthony J Freemont and Judith A Hoyland
Tissue, Injury and Repair, School of Clinical and Laboratory Sciences, Faculty of Medical and Human Sciences, Stopford Building, Oxford Road, The
University of Manchester, Manchester, M13 9PT, UK
Corresponding author: Judith A Hoyland, judith.a.hoyland@manchester.ac.uk
Received: 10 Jun 2008 Revisions requested: 11 Jul 2008 Revisions received: 23 Jul 2008 Accepted: 27 Aug 2008 Published: 27 Aug 2008
Arthritis Research Therapy 2008, 10:R99 (doi:10.1186/ar2487)
This article is online at: /content/10/4/R99
? 2008 Purmessur et al.; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Introduction The neurotrophins nerve growth factor (NGF) and
brain-derived neurotrophic factor (BDNF) have been identified in
the human intervertebral disc (IVD) and have been implicated in
Results Immunohistochemistry showed expression of NGF and
BDNF in the native chondrocyte-like cells in all regions of the
IVD and in all grades of degeneration. Interestingly only BDNF
significantly increased with the severity of degeneration (P
0.05). Similar expression was observed for Trk-A and Trk-B,
the
mechanisms
associated
with
nerve
ingrowth
and
nociception in degeneration of the IVD. The aim of the current
study was to investigate an association between neurotrophin
expression in the IVD and the severity of disc degeneration,
including the effect of disc-related proinflammatory cytokines on
neurotrophin and neuropeptide expression in cells derived from
the human IVD.
although
no
association
with
d
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