Experimental validation of convection-diffusion discretisation scheme employed for computational modelling of biological mass transport.docVIP

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Experimental validation of convection-diffusion discretisation scheme employed for computational modelling of biological mass transport.doc

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Experimental validation of convection-diffusion discretisation scheme employed for computational modelling of biological mass transport

Carrolletal.BioMedicalEngineeringOnLine2010,9:34 /content/9/1/34 RESEARCH OpenAccess Experimentalvalidationofconvection-diffusion discretisationschemeemployedfor computationalmodellingofbiologicalmass transport GráinneTCarroll1?,PaulDDevereux1,2?,DavidNKu2,TimothyMMcGloughlin1,MichaelTWalsh1* *Correspondence: michael.walsh@ul.ie 1CentreforAppliedBiomedical EngineeringResearch(CABER), DepartmentofMechanicaland Abstract Background:ThefinitevolumesolverFluent(Lebanon,NH,USA)isacomputational fluiddynamicssoftwareemployedtoanalysebiologicalmass-transportinthe AeronauticalEngineering,andthe MaterialsandSurfaceScience Institute,UniversityofLimerick, Limerick,Ireland vasculature.Aprincipalconsiderationforcomputationalmodellingofblood-side mass-transportisconvection-diffusiondiscretisationschemeselection.Dueto numerousdiscretisationschemesavailablewhendevelopingamass-transport numericalmodel,theresultsobtainedshouldeitherbevalidatedagainstbenchmark theoreticalsolutionsorexperimentallyobtainedresults. Methods:Anidealisedaneurysmmodelwasselectedfortheexperimentaland computationalmass-transportanalysisofspeciesconcentrationduetoitswell- definedrecirculationregionwithintheaneurysmalsac,allowingspecies concentrationtovaryslowlywithtime.Theexperimentalresultswereobtainedfrom fluidsamplesextractedfromaglassaneurysmmodel,usingthedirect spectrophometricconcentrationmeasurementtechnique.Thecomputationalanalysis wasconductedusingthefourconvection-diffusiondiscretisationschemesavailable totheFluentuser,includingtheFirst-OrderUpwind,thePowerLaw,theSecond- OrderUpwindandtheQuadraticUpstreamInterpolationforConvectiveKinetics (QUICK)schemes.Thefluidhasadiffusivityof3.125×10-10 m2/sinwater,resulting inaPecletnumberof2,560,000,indicatingstronglyconvection-dominatedflow. Results:Thediscretisationschemeappliedtothesolutionoftheconvection- diffusionequation,forblood-sidemass-transportwithinthevasculature,hasa significantinfluenceontheresultantspeciesconcentrationfield.TheFirst-Order Upwin