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Exogenous re-infection by a novel Streptococcus pneumoniae serotype 14 as a cause of recurrent meningitis in a child from The Gambia.doc

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Exogenous re-infection by a novel Streptococcus pneumoniae serotype 14 as a cause of recurrent meningitis in a child from The Gambia

Annals of Clinical Microbiology and Antimicrobials BioMedCentral Case report Open Access Exogenous re-infection by a novel Streptococcus pneumoniae serotype 14 as a cause of recurrent meningitis in a child from The Gambia Martin Antonio*, Claire Oluwalana, Ousman Secka, Tumani Corrah, Stephen Howie and Richard A Adegbola Address: Bacterial Diseases Programme, Medical Research Council Laboratories, Banjul, The Gambia, Africa Email: Martin Antonio* - mantonio@mrc.gm; Claire Oluwalana - coluwalana@mrc.gm; Ousman Secka - osecka@mrc.gm; Tumani Corrah - tcorrah@mrc.gm; Stephen Howie - showie@mrc.gm; Richard A Adegbola - radegbola@mrc.gm * Corresponding author Published: 20 January 2009 Received: 28 September 2008 Accepted: 20 January 2009 Annals of Clinical Microbiology and Antimicrobials 2009, 8:3 doi:10.1186/1476-0711-8-3 This article is available from: /content/8/1/3 ? 2009 Antonio et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract We report a case of an infant who experienced exogenous re-infection of Streptococcus pneumoniae serotype 14 as a cause of recurrent meningitis after apparently successful antibiotic treatment with ceftriaxone. eBURST analysis revealed that isolates from the two episodes of meningitis belonged to hypervirulent ST63 and ST3321 clonal complexes respectively. Background onstrate exogenous re-infection as a cause of recurrent meningitis in a child from The Gambia. Pneumococcal meningitis is common within the African meningitis belt and occurs in a seasonal pattern indistin- guishable from that of meningococcal meningitis [1]. Streptococcus pneumoniae can be subdivided by serological typing based on the capsular polysaccharide protein into at least 91 differe