Expression of leukemia inhibitory factor (LIF) and its receptor gp190 in human liver and in cultured human liver myofibroblasts. Cloning of new isoforms of LIF mRNA.docVIP

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Expression of leukemia inhibitory factor (LIF) and its receptor gp190 in human liver and in cultured human liver myofibroblasts. Cloning of new isoforms of LIF mRNA.doc

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Expression of leukemia inhibitory factor (LIF) and its receptor gp190 in human liver and in cultured human liver myofibroblasts. Cloning of new isoforms of LIF mRNA

Comparative Hepatology BioMedCentral Research Open Access Expression of leukemia inhibitory factor (LIF) and its receptor gp190 in human liver and in cultured human liver myofibroblasts. Cloning of new isoforms of LIF mRNA Toru Hisaka1,3,4, Alexis Desmoulière1,3, Jean-Luc Taupin2,3, Sophie Daburon2,3, Véronique Neaud1,3, Nathalie Senant3, Jean- Frédéric Blanc1,3, Jean-Fran?ois Moreau2,3 and Jean Rosenbaum*1,3 Address: 1INSERM, E362, Bordeaux, F-33076 France; Université Victor Segalen Bordeaux 2, Bordeaux, F-33076 France, 2CNRS, UMR 5164, Bordeaux, F-33076 France; Université Victor Segalen Bordeaux 2, Bordeaux, F-33076 France, 3IFR 66, 33076 Bordeaux France and 4Kurume University School of Medicine, Department of Pathology, Fukuoka, Japan Email: Toru Hisaka - toruhisaka@yahoo.co.jp; Alexis Desmoulière - alexis.desmouliere@gref.u-bordeaux2.fr; Jean-Luc Taupin - jean- luc.taupin@umr5540.u-bordeaux2.fr; Sophie Daburon - sophie.daburon@u-bordeaux2.fr; Véronique Neaud - veronique.neaud@gref.u- bordeaux2.fr; Nathalie Senant - nathalie.senant@bordeaux.inserm.fr; Jean-Frédéric Blanc - jean-frederic.blanc@chu-bordeaux.fr; Jean- Fran?ois Moreau - jean-francois.moreau@umr5540.u-bordeaux2.fr; Jean Rosenbaum* - jean.rosenbaum@gref.u-bordeaux2.fr * Corresponding author Published: 26 November 2004 Received: 02 July 2004 Accepted: 26 November 2004 Comparative Hepatology 2004, 3:10 doi:10.1186/1476-5926-3-10 This article is available from: /content/3/1/10 ? 2004 Hisaka et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The cytokine leukemia inhibitory factor (LIF) mediates its biological effects through binding to its high affinity receptor made of the low-affinity LIF receptor subunit gp190 (LIF-R) and the gp130 sub