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Exploring hepatic hormone actions using a compilation of gene expression profiles.doc

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Exploring hepatic hormone actions using a compilation of gene expression profiles

BMC Physiology BioMedCentral Research article Open Access Exploring hepatic hormone actions using a compilation of gene expression profiles Nina St?hlberg1, Roxana Merino1, Luis Henríquez Hernández2, Leandro Fernández-Pérez2, Albin Sandelin3, P?r Engstr?m3, Petra Tollet- Egnell1, Boris Lenhard3 and Amilcar Flores-Morales*1 Address: 1Department of Molecular Medicine, Karolinska Institute, 17176 Stockholm, Sweden, 2Health Sciences Center, Pharmacology Section, Las Palmas de GC University – Instituto Canario de Investigación del Cancer – RTICCC, 35080 – Las Palmas de GC, Spain and 3Center for Genomics and Bioinformatics, Karolinska Institute, 17176 Stockholm, Sweden Email: Nina St?hlberg - Nina.Stahlberg@cmm.ki.se; Roxana Merino - Roxana.Merino.Martinez@cmm.ki.se; Luis Henríquez Hernández - lhenriquez@becarios.ulpgc.es; Leandro Fernández-Pérez - lfernandez@dcc.ulpgc.es; Albin Sandelin - Albin.Sandelin@cgb.ki.se; P?r Engstr?m - Par.Engstrom@cgb.ki.se; Petra Tollet-Egnell - petra.tollet.egnell@cmm.ki.se; Boris Lenhard - Boris.Lenhard@cgb.ki.se; Amilcar Flores-Morales* - Amilcar.Flores@cmm.ki.se * Corresponding author Published: 13 June 2005 Received: 22 October 2004 Accepted: 13 June 2005 BMC Physiology 2005, 5:8 doi:10.1186/1472-6793-5-8 This article is available from: /1472-6793/5/8 ? 2005 St?hlberg et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Microarray analysis is attractive within the field of endocrine research because regulation of gene expression is a key mechanism whereby hormones exert their actions. Knowledge discovery and testing of hypothesis based on information-rich expression profiles promise to accelerate discovery of physiologically relevant hormonal mecha