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Expression of nm23 in the spectrum of pre-invasive, invasive and metastatic breast lesions.doc

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Expression of nm23 in the spectrum of pre-invasive, invasive and metastatic breast lesions

Diagnostic Pathology BioMedCentral Short report Open Access Expression of nm23 in the spectrum of pre-invasive, invasive and metastatic breast lesions Amanjit Bal*1, Kusum Joshi1, Rajesh Logasundaram1, BD Radotra1 and Rajinder Singh2 Address: 1Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India and 2Department of General Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India Email: Amanjit Bal* - docaman5@; Kusum Joshi - kus_joshi@; Rajesh Logasundaram - rlsundaram@; BD Radotra - bishanradotra@; Rajinder Singh - pgimer@chd.nic.in * Corresponding author Published: 30 May 2008 Received: 4 March 2008 Accepted: 30 May 2008 Diagnostic Pathology 2008, 3:23 doi:10.1186/1746-1596-3-23 This article is available from: /content/3/1/23 ? 2008 Bal et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Nm23 protein is a metastasis suppressor protein, expressed in all tissues. Reduced Nm23 expression is related to a high incidence of lymph node and distant metastasis and poor prognosis in patients with cancers. The present study was done to analyze the expression of Nm23 using immunohistochemistry in non-neoplastic and neoplastic breast lesions. Methods: Sections from 93 samples were studied and classified into non-proliferative breast lesion (13), fibrodenoma (7), proliferative breast lesion (13), carcinoma in situ (20), invasive carcinoma (23) and metastatic deposits in lymph nodes (17). Results: Nm23 expression in these groups showed a progressive down regulation with increasing neoplastic transformation. On comparing the various groups, nm23 expression was significantly different between the various subgr