Expression of novel extracellular sulfatases Sulf-1 and Sulf-2 in normal and osteoarthritic articular cartilage.docVIP

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Expression of novel extracellular sulfatases Sulf-1 and Sulf-2 in normal and osteoarthritic articular cartilage.doc

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Expression of novel extracellular sulfatases Sulf-1 and Sulf-2 in normal and osteoarthritic articular cartilage

Available online /content/10/3/R61 Research article Open Access Vol 10 No 3 Expression of novel extracellular sulfatases Sulf-1 and Sulf-2 in normal and osteoarthritic articular cartilage Shuhei Otsuki1, Noboru Taniguchi1, Shawn P Grogan1, Darryl DLima1, Mitsuo Kinoshita2 and Martin Lotz1 1Division of Arthritis Research, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA 2Department of Orthopedic Surgery, Osaka Medical College, 2–7 Daigaku-machi Takatsuki 569-8686, Osaka, Japan Corresponding author: Shuhei Otsuki, otsuki@ Received: 14 Jan 2008 Revisions requested: 18 Feb 2008 Revisions received: 4 Apr 2008 Accepted: 28 May 2008 Published: 28 May 2008 Arthritis Research Therapy 2008, 10:R61 (doi:10.1186/ar2432) This article is online at: /content/10/3/R61 ? 2008 Otsuki et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Changes in sulfation of cartilage 2 mRNA expression as compared with normal human articular cartilage. Sulf protein expression in OA cartilage was prominent in the cell clusters. Western blotting revealed a profound increase in Sulf protein levels in human OA cartilage. In normal mouse joints, Sulf expression was similar to human cartilage, and with increasing age, there was a marked upregulation of Sulf. glycosaminoglycans as mediated by sulfatases can regulate growth factor signaling. The aim of this study was to analyze expression patterns of recently identified extracellular sulfatases Sulf-1 and Sulf-2 in articular cartilage and chondrocytes. Methods Sulf-1 and Sulf-2 expressions in human articular cartilage from normal donors and patients with osteoarthritis (OA) and in normal and aged mouse joints were