Fabrication of Mesoporous Silica Shells on Solid Silica Spheres Using Anionic Surfactants and Their Potential Application in Controlling Drug Release.docVIP

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Fabrication of Mesoporous Silica Shells on Solid Silica Spheres Using Anionic Surfactants and Their Potential Application in Controlling Drug Release.doc

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Fabrication of Mesoporous Silica Shells on Solid Silica Spheres Using Anionic Surfactants and Their Potential Application in Controlling Drug Release

Molecules 2012, 17, 13199-13210; doi:10.3390/molecules171113199 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Fabrication of Mesoporous Silica Shells on Solid Silica Spheres Using Anionic Surfactants and Their Potential Application in Controlling Drug Release Ahmed Mohamed El-Toni 1,2,*, Aslam Khan 1, Mohamed Abbas Ibrahim 3, Mansour Al-Hoshan 1 and Joselito Puzon Labis 1 1 King Abdullah Institute for Nanotechnology, King Saud University, Riyadh 11451, Saudi Arabia 2 Central Metallurgical Research and Development Institute, CMRDI, Helwan 11421, Cairo, Egypt 3 Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assiut 71111, Egypt * Author to whom correspondence should be addressed; E-Mail: aamohammad@.sa; Tel.: +096-614-676-542; Fax: +096-614-670-663. Received: 12 September 2012; in revised form: 1 November 2012 / Accepted: 2 November 2012 / Published: 6 November 2012 Abstract: In this work, mesoporous shells were constructed on solid silica cores by employing anionic surfactante. A co-structure directing agent (CSDA) has assisted the electrostatic interaction between negatively charged silica particles and the negatively charged surfactant molecules. Synthetic parameters such as reaction time and temperature had a significant impact on the formation of mesoporous silica shelld and their textural properties such as surface area and pore volume. Core-mesoporous shell silica spheres were characterized by small angle X-ray scattering, transmission electron microscopy, and N2 adsorption–desorption analysis. The synthesized particles have a uniformly mesoporous shell of 34–65 nm and possess a surface area of ca. 7–324 m2/g, and pore volume of ca. 0.008–0.261 cc/g. The core-mesoporous shell silica spheres were loaded with ketoprofen drug molecules. The in vitro drug release study suggested that core-mesoporous shell silica spheres are a s