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Folliculo-stellate cells of true dendritic type are involved in the inflammatory microenvironment of tumor immunosurveillance of pituitary adenomas.doc

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Folliculo-stellate cells of true dendritic type are involved in the inflammatory microenvironment of tumor immunosurveillance of pituitary adenomas

Diagnostic Pathology BioMedCentral Short report Open Access Folliculo-stellate cells of true dendritic type are involved in the inflammatory microenvironment of tumor immunosurveillance of pituitary adenomas Istvan Vajtai*?1, Andreas Kappeler?2 and Rahel Sahli3 Address: 1Section of Neuropathology, Institute of Pathology, University of Bern, Switzerland, 2Laboratory of Diagnostic Immunohistochemistry, Institute of Pathology, University of Bern, Switzerland and 3Department of Endocrinology and Diabetology, University Hospital (Inselspital) Bern, Switzerland Email: Istvan Vajtai* - istvanvajtai@; Andreas Kappeler - kappeler@patho.unibe.ch; Rahel Sahli - sahli_rahel@ * Corresponding author ?Equal contributors Published: 27 June 2007 Received: 30 May 2007 Accepted: 27 June 2007 Diagnostic Pathology 2007, 2:20 doi:10.1186/1746-1596-2-20 This article is available from: /content/2/1/20 ? 2007 Vajtai et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Folliculo-stellate cells are a nonendocrine, sustentacular-like complementary population of the anterior pituitary. They currently are considered as functionally and phenotypically heterogeneous, with one subpopulation of folliculo-stellate cells possibly representing resident adenohypophyseal macrophages. We took advantage of a limited T-cell mediated inflammatory reaction selectively involving tumor tissue in three cases of pituitary adenoma (2 prolactin cell adenomas, and 1 null cell adenoma) to test the hypothesis whether some folliculo-stellate cells within inflammatory foci would also assume monocytic/dendritic properties. Immunohistochemical double labeling for S-100 protein and the class II major histocompatibility antigen HLA-DR indeed showed