Fluvoxamine for blonanserin-associated akathisia in patients with schizophrenia report of five cases.docVIP

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Fluvoxamine for blonanserin-associated akathisia in patients with schizophrenia report of five cases.doc

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Fluvoxamine for blonanserin-associated akathisia in patients with schizophrenia report of five cases

Furuse and Hashimoto Annals of General Psychiatry 2010, 9:17 /content/9/1/17 CASE REPORT Open Access Fluvoxamine for blonanserin-associated akathisia Case report in patients with schizophrenia: report of five cases Tsutomu Furuse*1 and Kenji Hashimoto2 Abstract Background: Atypical antipsychotic drugs have been reported to cause fewer incidences of extrapyramidal side effects (EPS) than typical antipsychotic drugs, but adverse events such as akathisia have been observed even with atypical antipsychotic drugs. Although understanding of the pathophysiology of akathisia remains limited, it seems that a complex interaction of several neurotransmitter systems plays a role in its pathophysiology. The endoplasmic reticulum protein sigma-1 receptors have been shown to regulate a number of neurotransmitter systems in the brain. Methods: We report on five cases in which monotherapy of the selective serotonin reuptake inhibitor and sigma-1 receptor agonist fluvoxamine was effective in ameliorating the akathisia of patients with schizophrenia treated with the new atypical antipsychotic drug blonanserin. Results: The global score on the Barnes Akathisia Scale in five patients with schizophrenia treated with blonanserin rapidly decreased after fluvoxamine treatment. Conclusion: Doctors should consider that fluvoxamine may be an alternative approach in treating akathisia associated with atypical antipsychotic drugs. Background aminobutyric acid (GABA), and neuropeptides) underlies its complex pathophysiology [1,2]. Atypical antipsychotic drugs have been reported to cause a fewer incidences of extrapyramidal side effects (EPS) than typical antipsychotic drugs, but adverse events such as akathisia have been observed even with atypical antip- sychotic drugs. Akathisia is one of the common and dis- The endoplasmic reticulum protein sigma-1 receptors play a key role in Ca2+ signaling and cell survival, and have been shown to regulate a number of neurotransmitt