非小细胞肺癌“寡转移”的概念及治疗策略.pdfVIP

.242. 中间肺癌杂志20JZ年4 片第15 卷第4期 Chin_j_ Lung Cancer, April 2012 , Vo 1.!5, No .4 ·综述· 非小细胞肺癌寡转移的概念及治疗策略 康晓征陈先能 I 摘要l 非小细胞肺癌是发病率及致死率最高的恶性肿瘤之→c 约2阳50%会发生远处转移，最常见的转移 部fv:为脑、骨.肝及肾 k 腺二寡转移状态是一段肿瘤生物侵袭性较温和I 的时期，存在于局限性原发炕与r 泛性转 移之间的过渡阶段.转移瘤数同有限并且转移器自具有特异性。寡转移来源于徽转移，肿瘤细胞已具有器官特异 性.但尚不具备全身播散的遗传倾向。怡疗寡转移状态的关键是局部控制，需要兼顾而i 防远处转移、治疗隐匿性 转移灶、治疗寡转移灶和今:身治疗结束后清除残留册址四个方面。本文旨在对寡转移概念在非小细胞肺癌常见转 移脏器治疗中的山用作-综述。 I 关键词]肺肿瘤;肿瘤转移:治疗;放疗 I 申固分类号 1 R734.2 The Conceptual Oligometastatic Non-small Cell Lung Cancer and Therapeutic 5trategies Xiaozheng KANG ,Keneng CHEN y Laboraωη of Ca.巾。gen臼is and Translational Rfiearch (Ministry of Ed皿ation)， 1horaciι Surg町1， Peking Universi抄 Cancer Hospital lnsti阳缸Beijing 100142, China CO白， ;ponding author: Keneng CHEN, E-mail: chenkeneng@.CtI [ Abstract 1 Non-small celllung canC.r (NSCLC) ranks among the most pr，凹alent malignancies and is the major cause of cancer-related deaths worldwide. Nearly 20%-50% will accompany by metastatic disease and the mo目 commonex. trapulmonary 副tes of dislant melastases are the brain,bone , liver and adrenal gI扭d 币le oligometastatic slate is a biologically mild tumor stage and a intermediate state in which spread may be limiled 10 specilic organs and metastases miglll be present 皿 捡回恒d nwnbers. Oligometastases are thought to 皿50 from rnicrometastases ,which have been dormant for a period of time. Local control may be an crucial component of a curative therapeutic strategy in the f