Genome interrupted sequencing of prostate cancer reveals the importance of chromosomal rearrangements.docVIP
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Genome interrupted sequencing of prostate cancer reveals the importance of chromosomal rearrangements
Kumar et al. Genome Medicine 2011,3:23
/content/3/4/23
RESEARCH HIGHLIGHT
Genome interrupted: sequencing of prostate
cancer reveals the importance of chromosomal
rearrangements
Akash Kumar , Jay Shendure and Peter S Nelson*
1 1 2
e genomes of a number of carcinomas, including
breast, lung and skin, have been sequenced (Table 1).
ese studies have provided fascinating insights into
tumor biology, and have identi?ed new leads for diag -
nosis and therapy [2-4]. A recent Nature article by
Berger and colleagues [1] details the ?rst whole genome
study of prostate cancer. e work builds on earlier
?ndings concerning the genetic make-up of cancers
and highlights aspects that appear to be unique to
prostate tumors.
Abstract
A recent study involving whole genome sequencing
of seven prostate cancers has provided the rst
comprehensive assessment of genomic changes
that underlie this common malignancy. Point
mutations were found to be infrequent but
changes in chromosome structure were common.
Rearrangements were linked to chromatin organization
and associated with regions involved in transcription
factor binding. Novel candidate prostate cancer genes
were also identied, highlighting the importance of
genome sequencing to identify oncogenic changes
that are otherwise invisible to detection.
Relatively few point mutations in prostate cancer
Berger et al. [1] sequenced the genomes of seven high-
grade aggressive primary prostate cancers and corres-
ponding normal tissues by generating approximately
30-fold genome coverage of paired-end, short-read
sequencing on the Illumina platform. After mapping
reads to the human reference genome, they found that
each cancer genome possessed on average less than one
somatic point mutation per megabase. is mutation rate
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