Treatingprimaryhypothyroidism.PDF

original article Treating primary hypothyroidism with weekly doses of levothyroxine: a randomized, single-blind, crossover study Tratamento de hipotiroidismo primário com doses semanais de levotiroxina: um estudo randomizado, unicego, crossover 1 2 1 1 Andressa Bornschein , Gilberto Paz-Filho , Hans Graf , Gisah A. de Carvalho ABSTRACT 1 Serviço de Endocrinologia Objective: Compliance to levothyroxine treatment in hypothyroidism is compromised by daily e Metabologia, Hospital de schedule, and a weekly dose may be an alternative. Subjects and methods: This was a ran- Clínicas, Universidade Federal do Paraná (SEMPR/HC- domized, crossover study. Fourteen females were assigned to daily or weekly doses of LT4. UFPR), Curitiba, PR, Brazil After six weeks, they switched regimens. Thyroid parameters were measured at baseline, and 2 The John Curtin School after 42 and 84 days. Echocardiogram and hyperthyroidism symptoms were evaluated before of Medical Research, and four hours after LT4 intake. Results: In the weekly dose treatment, fT4 levels were higher Australian National University, Canberra, ACT, Australia after taking LT4, and lower seven days after the last dose; by the 6th week there was a small de- cr