注射用鼠神经生长因子治疗慢性多发性周围神经病的初步临床评价.pdfVIP

• 80 • Stroke and Nervous Diseases , Apr 20日，VoL 20 ,No. 2 注射用鼠神经生长因子治疗慢性多发性周围 神经病的初步临床评价 林措胡晓晴张吏李悦唐娜卡碧涛 E摘要】 目的 了解鼠神经生长因子治疗慢性多发性周围神经病的疗效。方法 对60 例慢性多发性周 围神经病患者进行随机和意愿分组，对照组28 例，采用基础治疗，而 32 例治疗组则增加肌肉注射鼠神经生长 因子(苏肤生，30 I岖，QD，连续 2-4 周) ，治疗 4 周后评价运动功能(MMT评分)、日常生活能力。气DL 改良)、 末梢型感觉障碍范围及疼痛程度(VAS、 McGill)等。结果 两组病例在治疗4 周后 MMT、 ADL评分、四肢末 梢型感觉障碍的范围、疼痛程度均改善，其中治疗组在四肢末梢型感觉障碍的范围及疼痛程度改善较对照组 明显.结论 在进行基本治疗的基础上加用鼠源性神经生长因子至少2 周，能进一步改善感觉功能障碍，包 括使感觉障碍的面积缩小、缓解神经痛和提高患者生活质量，然而其对运动功能改善似乎不明显。 E关键词】慢性多发型周围神经病 鼠神经生长因子 E申图分类号] R745 【文献标识码] A [文章编号】 1007-0478(2013)02-0080H04 [001] 10. 3969/j. issI1. 1007-0478.2013.02.004 岛、eliminary 跑跑翩翩tofeffiα副cyof 田跚跚跚咽growth factor tr四trnent 011 chronic 阳ipheral polyneur吨F a由yinacliniωI 仕iaI Lin ] ing , Hu Xiaoqing , Zhang Min , et al. Deρartment of Neurology , Tongji Hos- ρital ， Tongji Medical College , Hωzhong university of science and Technology , Wuhan 430030 [Abs缸-act]ω~ec伽e To assess the efficacy of nerve growth factor treatment on chronic peripheral polyneuropathy. Methods Sixty patients with chronic peripheral polyneuropathy were divided into two groups randomly 皿d willingly. Twenty-eight patients in the control group were treated with basic medicine ,and 32 patients in the treatment group were added intramuscular injection of mouse nerve growth factor (Su peptide , 30 ug , QD , 2-4 consecutive weeks) in addition to basic treatment Motor function (MMT score) , ability of daily life (modified ADL) , the range of peripheral sensory disturbance and the degree of pain (VAS , McGill) were evaluated in all these patients after 4 weeks. 部副ts MMT , ADL score , the range of limbs peripheral sensory disturbance and the