脑脓肿一--台湾_洪桢邦.pptVIP

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脑脓肿一--台湾_洪桢邦

presented by Ri 洪楨邦 Introduction A focal collection of pus surrounded by a well-vascularized capsule (encephalitis: inflammation of brain) The brain is remarkably resistant to bacterial and fungal infection∵ - abundant blood supply - blood-brain barrier (simple bacteremia is very rare) Brain abscess -Pathophysiology 1 Direct spread from adjacent infection (20~60 % , via valveless emissary veins to cavernous sinus) 2 Hematogenous spread 3 Penetrating brain injury 4 Neurosurgery-related 5 Cryptic (20%~30%) Direct spread Hematogenous spread … Most commonly in MCA territory Chronic pulmonary infection: lung abscess, empyema or bronchiectasis Skin infection Pelvic infection Intraabdominal infection Endoscopic sclerosis of esophageal varices Bacterial IE Cyanotic congenital heart disease (children) Furen Xiao, Ming-Yuan Tseng, Lee-Jene Teng, Ham-Min Tseng, Jui-chang Tsai, Brain abscess: clinical experience and analysis of prognostic factor Surgical neurology 63(2005):442~450 Collect data from 1986~2002 178 pt(130 males and 48 females) Age: 2 months to 84 years 60 % aged 20~60 y/o, 9%10 y/o Clinical Manifestation Clinical Triad of brain abscess only in 13% Headache(70~95%): dull aching, generalized, with N/V; severe and refractory to NSAID; but not as abrupt as SAH or acute meningitis Fever(60%): not reliable indicator Focal neurological deficit(45%): hemiparesis, aphasia, visual disturbance Seizure on admission (16%) Neck stiffness(15%); Papilledema(23~50%) Clinical Manifestation Nonspecific, dx is made at a mean of 11 days (1~60 d) after the onset of symptoms GCS on admission: wide range: GCS 15(65%), 14(6%), 9~13(17%), 5~8(11%) PE: Cranial vault infection dental abscess, otitis media, or sinusitis CN III, VI deficit ? IICP Sudden worsening of pre-existing headache: abscess rupture into ventricle Brain abscess -Laboratory Little value in the diagnosis Mild leukocytosis 20,000 per mm3 B/C only positive in 15 % Lumb

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