利培酮联合氟伏沙明治疗抽动障碍29例疗效分析_0.docVIP

利培酮联合氟伏沙明治疗抽动障碍29例疗效分析 作者：常双海 寇建华 杜亚松 【关键词】 抽动障碍；利培酮；氟伏沙明 　　【摘要】 目的 探讨利培酮联合氟伏沙明 治疗 抽动障碍的疗效及安全性。 方法 将29例抽动障碍患儿随机分为利培酮联合氟伏沙明治疗组15例及利培酮治疗组14例，观察治疗8w，采用耶鲁抽动症严重程度量表及副反应量表评定临床疗效和不良反应。 结果 耶鲁抽动症严重程度量表评定，治疗4、8w末两组运动抽动和发声抽动的五个要素评分均较治疗前有显著或极显著性下降（P＜0.05或0.01）；治疗4w末 研究 组损伤因子、总分均较对照组下降显著（P＜0.01）；治疗8w末频率、干扰度要素及运动、发声、损伤因子和总分评分均显著低于照组（P＜0.01），两组不良反应发生率均较低，且程度较轻。结论 利培酮联合氟伏沙明治疗抽动障碍起效快，疗效增加，安全性高，依从性好。 【关键词】 抽动障碍；利培酮；氟伏沙明 Curative effects of risperidone plus fluvoxamine in 29 patients with tic disorders 【Abstract】 Objective To explore curative effects and safety of risperidone combining with fluvoxamine in the treatment of tic disorders. Methods 29 patients with tic disorders were randomly treated with risperidone plus fluvoxamine(n=15) and risperidone (n=14) for 8 weeks. Curative effects and adverse reactions were assessed with the Yale Global Tic Severity Scale(YGTSS) and the Treatment Emergent Symptom Scale(TESS) respectively. Results At the ends of the 4th and 8th week,5 essence scores of motor tics and laryngeal tic decreased significantly or very significantly for both two groups (P＜0.05 or 0.01 ). At the end of 4th week, damage factor score and total score decreased more significantly in the research group than did in the control group (P＜0.01). At the end of 8th week, essence scores of frequency and interference, factor scores of motor, laryngeal and damage and total score were significantly lower in the research than in the control(P＜0.01).Incidence of adverse reactions were lower and milder for both 2 groups. Conclusion Risperidone plus fluvoxamine takes effects faster, increases curative effects and has higher safety and better compliance in the treatment of tic disorders. 【Keywords】 Tic disorders；risperidone；fluvoxamine 　　抽动障碍是儿童少年时期常见的一种神经精神疾病，主要表现为不自主的、反复的、快速的、无目的的一个或多个部位肌肉运动性抽动或（和）发声性抽动，可伴有多动、注意力不集中、 学习 困难、强迫性动作和思维及其他行为症状。在学龄前儿童中，≥5%的儿童有抽动症状［1］，且发病后症状控制缓慢，易导致患儿学习、生活和 社会 交往困难，给家庭带来很大的心理负担。近年来，对抽动症的研究很多，我们 应用 利培酮联合氟伏沙明治疗抽动障碍，取得了较好的疗效，现将结果报告如下。 1 对象与方法 1.1 对象 选取2