卵巢上皮性肿瘤中B7-H4表达及临床意义.docVIP

卵巢上皮性肿瘤中B7-H4表达及临床意义 作者：王永丽 梁建芳 郑绘霞 肖虹 程彩霞 李宁 【摘要】 目的：探讨B7-H4在卵巢癌中的表达及其临床病理意义。方法：采用免疫组织化学染色PV6000法检测13例正常卵巢组织、20例卵巢良性上皮性肿瘤组织、20例卵巢交界性上皮性肿瘤组织、40例卵巢癌组织标本中B7-H4的表达，并对其中40例卵巢癌B7-H4的表达与年龄、组织学类型、病理分期、分级及淋巴转移和患者预后之间的关系进行统计学分析。结果：B7-H4在正常卵巢组织、卵巢良性上皮性肿瘤、交界性上皮性肿瘤及卵巢癌组织中的阳性表达比例分别为7.7% (1/13)、20%(4/20)、60% (12/20)、90% (36/40)，交界性及恶性标本阳性比例明显高于非恶性标本，差异有统计学意义(P0.05)。40例卵巢癌标本中浆液性癌、内膜样癌、透明细胞癌、黏液性癌的B7-H4蛋白阳性比例分别为23/23、3/3、6/6、4/8，黏液性癌的蛋白阳性比例明显低于前三组，差异有统计学意义(P0.05)。B7-H4在卵巢癌期～期的阳性表达率显著高于卵巢癌期～期，差异有统计学意义(P0.05)。结论：40例卵巢癌组织中B7-H4的表达与组织学类型、病理分期及预后相关，而与年龄、病理分级和淋巴结转移等无关。B7-H4抑制了卵巢癌组织中肿瘤浸润淋巴细胞的功能，其有可能成为辅助卵巢癌诊治的新的靶目标。 【关键词】 B7-H4；肿瘤浸润淋巴细胞；卵巢上皮性肿瘤；免疫组织化学 Expression of B7-H4 in Epithelial Tumor of Ovary Wang Yongli,Liang Jianfang,Zheng Huixia,et al. Department of Pathology, First Clinical Medical College,Shanxi Medical University Abstract Objective:To evaluate the expression of B7-H4 in epithelial ovarian tumor and the relationship between B7-H4 expression and the clinicopathological variables.Methods:Archival tissue blocks from 93 epithelial ovarian tumor patients including 13 normal ovarian tissues,20 benign tumors,20 borderline tumors,23 serous carcinomas,3 endometrioid carciniomas,6 clear cell carcinomas and 8 mucinous carcinoma were evaluated by immunohistochemistry PV6000 for the expression of B7-H4,and to analyze thEir relationship with age,histology type,pathology stage,cell differentiation,lymphametastasis and patient prognosis.Results:⑴ The expression of B7-H4 in 13 normal ovarian tissues,20 benign tumors,20 borderline tumors and 20 ovarian cancers was 7.7%(1/13),20%(4/20),60% (12/20),90% (36/40)respectively.The expression of B7-H4 was higher in ovarian cancer than in ovarian borderline tumor and benign tumor(P0.05).⑵The expression of B7-H4 in 23 serous carcinomas,3 endometrioid carciniomas,6 clear cell carcinomas and 8 mucinous carcinoma was 23/23,3/3,6/6,4/8 respectively(P0.05).⑶The expression of B7-H4 decreased significantly in stage Ⅰ and of stage Ⅱ ovarian cancer,compa