秦子迪j佳大药学毕业论文.docVIP

毕业论文（设计） 论文题目 丹参酮IIa磺酸钠微量杂质的分离及结构鉴定 专 业 药学 班 级 2015级 指导教师 学生姓名 秦子迪 佳木斯大学继续教育学院  丹参酮IIa磺酸钠微量杂质的分离及结构鉴定： Separation of Microimpurity and Identification of Sodium Tanshinone IIa Sulfonate Abstract: Salvia miltiorrhiza is one of the most important tradition Chinese medicinal materials that possess the function of both promoting blood flow and removing blood stasis with anti-coronary artery disease. The consumed quantity only in the aspect of injection has been exceeded 2 billion dosages every year. However, because the undetermined active ingredients and relaxed index of quality control induced the instable effects of clinic traterment, and, moreover, usually adverse functions, which lead salvia miltiorrhiza unable to accommodate requirement of contemporary Chinese medicinal materials melting world. Sulfotanshinone sodium is asodium chloride of water-solubility after sulfonating tanshinone IIa of liposolubility active ingredien tabstraeted in salvia miltiorrhiza.It is an effective medicine of angiocardiopathy to treat coronary artery disease, anginacordis，and myocardial infarction.The amount of clincal utilization continuous. increasing with the high proportion of patients of angiocardiopathy induces raw material resource of salvia miltiorrhiza insufficient in China. So it becomes an extensive focus point in fharmaceutical factory that sufficient utilize and cut down uymost dissipation resource of salvia miltiorrhiza. Keywords:1-Hydroxy-Tanshinone IIa sulfonate ; sodium tanshinoneⅡA sulphonate(STS);tanshinoneIIa;separation;identification  目 录 摘要参考文献致谢1,2]。 第一章文献综述 1.1 丹参形态 丹参是唇形科鼠尾草属植物丹参(Salvia miltiorrhiza Bge．)的干燥根及根茎。该属植物约900-1100种，主要分布于热带或温带。我国有约84种，分布于全国各地，尤以西南为多。除了丹参外，三叶鼠尾草，云南鼠尾草的根也可以作为丹参入药。其植物学性状和产地如下[6,7]（见图1）： 图1 多年生直立草本；根肥厚，肉质，外面朱红色，内面白色，长5-15厘米，直径4