氟康唑注射液致严重过敏反应1例.pdfVIP

中国药物应用与监测 2014 年12月第11卷第6 期 Chinese Journal of Drug Application and Monitoring, Vol.11, No.6, December 2014 ·病例监测 · 氟康唑注射液致严重过敏反应1 例 邓牡红，黄芳芳，陈志杰，李秀秀（解放军总医院肿瘤内二科，北京100853 ） [摘要] 1例 45 岁男性患者，因确诊肺癌入院，此次化疗同时行颅脑放疗。患者咽拭子及大便中检出真菌，给予氟康唑注射 液（100 mg，ivgtt ）抗真菌治疗。在输注结束2 min 后，患者出现寒战、高热、喘憋、剧烈咳嗽等症状，考虑为严重过敏反应， 立即给予持续吸氧（4 L·min-1 ），地塞米松磷酸钠注射液（5 mg ，iv ）、盐酸苯海拉明注射液（1 mL，im ）、二羟丙茶碱注射液 （0.25 g ，ivgtt ）、注射用甲泼尼龙琥珀酸钠（40 mg ，iv ）、注射用赖氨匹林（0.9 g ，iv ）等对症治疗。之后患者症状逐渐缓解，3 h 后症状消失。 [关键词] 肺癌；氟康唑注射液；严重过敏反应；药品不良反应 [ 中图分类号] R978.1 [ 文献标识码] B [ 文章编号] 1672 – 8157(2014)06 – 0390 – 02 One case of serious anaphylaxis induced by fluconazole injection DENG Mu-hong, HUANG Fang-fang, CHEN Zhi-jie, LI Xiu-xiu(Department of Medical Oncology, PLA General Hospital, Beijing 100853, China) [ABSTRACT] One 45-year-old male patient diagnosed with lung cancer received chemotherapy and radiotherapy. Throat swab culture and stool culture confirmed fungal infections and fluconazole injection (100 mg, ivgtt) was given for antifungal therapy. Two minutes after the end of infusion, the patient complained of shiver, hyperpyrexia, suffocation and severe cough, which was considered as severe allergic reaction. Inhalation of oxygen (4 L min-1), dexamethasone sodium phosphate injection (5 mg, iv), diphenhydramine · hydrochloride injection (1 mL, im), diprophylline injection (0.25 g, ivgtt), methylprednisolone sodium succinate for injection(40 mg, iv) and lysine acetylsalicylate for injection (0.9 g, iv) were given. Then the patient recovered gradually and the above symptoms disappeared 3 h later. [KEY WORDS] Lung cancer; Fluconazole injection; Severe allergic reaction; Adverse drug reaction 时间较短，范围窄，调查人群特殊，结果可能有一定 hospitalization and as outpatients[J]. Qual Life Res, 2000, 9(9): 的局限性，在今后的工作中将做更进一步的调研。