DNA损伤，修复和重组.pptVIP

4．DNA damage, repair and recombination Including 4.1 Mutagenesis(诱变) 4.2 DNA damage 4.3 DNA repair 4.4 DNA Recombination 4.5 DNA Transposition 4.1 Mutagenesis 4.1.1 Mutation 4.1.2 Physical mutagens 4.1.3 Chemical mutagens 4.1.1 Mutation Mutations are permanent, heritable alterations in the base sequence of the DNA. Piont mutation — a single base change. Transition (转换) – one purine (or pyrimidine ) is replaced by the other Transversion（颠换）-- a purine replaces a pyrimidine or vice versa Silent mutation– no effect on the amino acid incorporated into a protein. （突变对表达结果不产生影响）