Section 4 Autoimmune Diseases课件.pptVIP

Section 4 Autoimmune Diseases 1. Definition: An immune reaction against “ self-antigens” is the cause of certain diseases in human. 2. Mechanism (1) Alteration of self-proteins (modification of the molecule) ① Partial degradation of autoantigens. ② Complexing of self-antigens with drugs or micro-organisms. (2) Hidden antigens exposure (3) Cross-reactions (molecular mimicry) ① Antibodies to streptococcal antigens may react with constituents of cardiac muscle or connective tissue in rheumatic fever. ② Rabies vaccine may rise to encephalitis (4) Breakdown of tolerance ① Bypass of he