92-第二章 造血与血细胞分化发育(国外英文资料).doc

92-第二章 造血与血细胞分化发育 Chapter ii hematopoiesis and blood cell development One, the hematopoietic organ and the hematopoietic microenvironment Tissue organs that can produce and support the differentiation, development and maturity of hematopoietic cells are called hematopoietic organs. The process of generating blood cells from hematopoietic organs is called hematopoiesis. Embryo hematopoietic embryo can be divided into three different hematopoietic periods. (1) the hematopoietic period of the embryo is about the second weekend of the development of human embryonic development, until the 9th week of the human embryo. The outer mesodermal cells of the follicle wall are undifferentiated, self-renewing cells, which aggregate into a mass called a blood island. The blood island was the first blood center of human blood. (2) the period of hepatic hematopoiesis begins in the 6th week of the embryo and degrades in the 7th month of the embryo. Hepatic hematopoiesis occurs when hematopoietic stem cells produced by the follicle island of the yolk are migrated to the liver after the blood flow to the liver, causing blood to be hematopoietic. 3 months ~ 6 months of foie gras is the main hematopoietic site in the body. (3) the bone marrow has been hematopoietic in the first three months of the embryo, and as the embryo develops, bone marrow hematopoiesis develops. 8 months, the bone marrow hematopoietic has highly development, dense in the medullary cavity of hematopoietic cells and hematopoietic cells of different disciplines are visible to the oven, the lack of fat, then become bone marrow hematopoietic center, from the liver, spleen hematopoiesis function decline, the bone marrow hematopoietic increase rapidly. Three hematopoietic when the embryo stage is not separated, but alternating related to each other, the order of the various types of blood cells form are: red blood cells, granulocytes, megakaryocyte, lymphocytes and monocytes. Hematopoietic organs after birth (1) bone mar