丽珠胃三联(国外英文资料).docVIP

丽珠胃三联 For indications are widely distributed in the body, in the reproductive organs, gut, abdominal muscles and can reach high levels in breast milk, low concentration in the liver, fat, in the same period, concentration in saliva and blood concentrations of bile, penetrability of the blood-brain barrier relatively high metronidazole, meningeal no inflammation in the cerebrospinal fluid at the concentration of blood drug concentration of 80%, which is associated with higher for indications of fat-soluble. It can reach high concentrations in fetuses and placenta through the blood placenta barrier. The protein binding rate was 12%. In hepatic metabolism, about 16 percent of a single dose of oral 0.25 g is in the urine. The blood elimination half-life (t1/2 beta) was 11.6 ~ 13.3 hours, averaging 12.6 hours. Clamycin tablet: the gastrointestinal tract is rapidly absorbed by the oral, and the bioavailability (F) is 55%. Food may be delayed, but not in bioavailability. A single dose of an oral 4, 400mg and 2.7 hours of blood supply peak (Cmax) 2.2 mg/L; Oral 250 mg every 12 hours, in 2 ~ 3 days to reach the steady state of blood concentration of about 1 mg/L and its metabolites (14 - hydroxy clarithromycin) 0.6 mg/L, oral 500 mg every 12 hours, average drug in steady state peak plasma concentration is 2.7 ~ 2.9 mg/L, the metabolites of 0.83 ~ 0.88 mg/L. In the body, the concentration of drugs in the mucosa, tonsils and lung tissue is higher than the blood concentration. In plasma, the protein binding rate is 65 to 75 percent. The main metabolite is 14-hydroxycyclomycin, which has the active function of the large ring. A single dose removes the half-life of the blood after the drug. 4.4 hours; The blood of the original drug at 250mg/day is eliminated (t1/2 ?;). For 3 to 4 hours, the metabolites are 5 to 6 hours; The blood of the original drug of 500mg per 12 hours is eliminated in half life (t1/2 szlig;;) For 4.5 to 4.8 hours, the metabolites were 6.9 to 8.7 hours. By o