类风湿关节炎(国外英文资料).docVIP

类风湿关节炎 Rheumatoid arthritis Rheumatoid arthritis is a chronic inflammatory disease that is characterized by the symmetry of the surrounding joints, and can be accompanied by systemic damage outside the joint. The histopathology of histopathology, which occurs when cartilage and bone are deformed. Rheumatoid factors appear in the serum. Its an autoimmune disease. (a) the cause The cause is unknown. It may be related to the following factors. 1. The factors such as mycoplasma infection, mycobacterium, intestinal bacteria, EB virus, HTLV  I and other retroviruses are suspected to cause the disease pathogens, but failed to find corroboration. 2. The susceptibility to the disease susceptibility is related to genetic basis that Ⅱ HLA class. (2) the incidence of rheumatoid arthritis of the pathogenesis and the effect of the pathogen and genetic gene interaction are not the result. The following hypothesis shows the interaction between the two: the HLA can be a receptor for certain pathogens; The antigens of the pathogen combine with the amino acids of the HLA molecule; (3) molecular simulation, namely the HLA molecules associated with diseases and pathogens has the similar structure genes, such as HLA  DR4 certain subtypes between shell and epstein-barr virus antigen (gP110) is a segment of the same amino acid, the antigen of antibody response to pathogens to on its own immune response. After the antigen enters the body is first or scavenger cells macrophage, after digestion, concentration and cell membrane of HLA  DR molecules combined into complex, if the compounds by the T cell receptor recognition, was the auxiliary lymphocyte activation, cause a series of immune reaction, including activation of B lymphocytes, make its differentiation into plasma cells, secrete a large number of immune globulin, including rheumatoid factor (rheumatoid factor). The rheumatoid factor is an antibody to IgGFc, an immunoglobulin, which binds to its IgG and is an antibody of its own. Th