剂量-反应关系Meta分析方法学简介.pdfVIP

Methodology Chin J Evid-based Med 2015, 15(10): 1236-1240 剂量-反应关系Meta分析的方法学简介 1,2 3 4 1,5 3 1* 徐畅 ，张永刚，韩芳芳，牛玉明 ，邝心颖，张超 1. 湖北医药学院附属太和医院循证医学中心（湖北十堰 442000 ）；2. 武汉大学中南医院泌尿外科（武汉 430071 ）； 3. 四川大学华西医院（成都 610041 ）；4. 武汉大学中南医院眼科（武汉 430071 ）； 5. 湖北医药学院附属太和医院口腔科（湖北十堰 442000 ） 摘要 剂量- 反应关系Meta 分析已有30 余年的发展史，其实质是一种回归函数，这种回归既可以是线性， 也可以是非线性。剂量- 反应Meta 分析在探讨自变量与应变量关系中起着十分重要的作用，并以其独特的优点被 广泛应用于循证实践及决策。目前，有多种函数模型可用于剂量- 反应Meta 分析，不同模型存在不同的优缺点。 在循证实践中，根据不同数据分布选择不同模型尤为重要。本文对剂量- 反应关系Meta 分析的方法进行简介。 关键词  剂量- 反应关系；Meta 分析；方法学 How to Perform Dose-response Meta-analysis: A Brief Introduction of Methodology 1,2 3 4 1,5 3 1* XU Chang , ZHANG Yong-gang , HAN Fang-fang , NIU Yu-ming , KUANG Xin-ying , ZHANG Chao 1. Center for Evidence-based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China; 2. Department of Urology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China; 3. West China Hospital, Sichuan University, Chengdu 610041, China; 4. Department of Ophthalmology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China; 5. Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China Abstract Does-response meta-analysis, which has being developed for more than 30 years, is a type of regression function and can be both linear and non-linear model. It plays an important role in investigating the relationship between dependent and independent variable. With its special advantages, dose-response meta-analysis has been widely used in evidence-based practice and decision. Currently there are several models can be used to perform dose-response meta- analysis with various advantages and disadvantages. It is vital to choose best model to perform dose-response meta- analysis in ev